Technology Process of 1-(2-amino-5-(4-fluorobenzoyl)phenyl)-2,2,2-trifluoroethanone
There total 4 articles about 1-(2-amino-5-(4-fluorobenzoyl)phenyl)-2,2,2-trifluoroethanone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
ammonia;
In
dimethyl sulfoxide;
at 100 ℃;
for 2.01h;
Sealed tube;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: tetrahydrofuran / 0.11 h / 20 °C / Cooling with acetone-dry ice; Inert atmosphere
1.2: 0.54 h / Cooling with acetone-dry ice; Inert atmosphere
2.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hypochlorite; potassium bromide; sodium hydrogencarbonate / dichloromethane; water / 0.42 h / Cooling with ice
3.1: ammonia / dimethyl sulfoxide / 2.01 h / 100 °C / Sealed tube
With
sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; ammonia; sodium hydrogencarbonate; potassium bromide;
In
tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hypochlorite; potassium bromide; sodium hydrogencarbonate / dichloromethane; water / 0.42 h / Cooling with ice
2: ammonia / dimethyl sulfoxide / 2.01 h / 100 °C / Sealed tube
With
sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; ammonia; sodium hydrogencarbonate; potassium bromide;
In
dichloromethane; water; dimethyl sulfoxide;
