tert-butyl ((1R,4R)-4-((5-bromo-3-(((4,6-dimethyl-2-oxo-1,2-dihydro-3-yl)methyl)carbamoyl)-2-methylphenyl)(ethyl)amino)cyclohexyl)carbamate

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Chemical Name:tert-butyl ((1R,4R)-4-((5-bromo-3-(((4,6-dimethyl-2-oxo-1,2-dihydro-3-yl)methyl)carbamoyl)-2-methylphenyl)(ethyl)amino)cyclohexyl)carbamate
CAS No.:1403258-29-6
Molecular Formula:C₂₁H₃₁BrN₂O₄
Molecular Weight:455.392
Hs Code.:

Synonyms:tert-butyl ((1R,4R)-4-((5-bromo-3-(((4,6-dimethyl-2-oxo-1,2-dihydro-3-yl)methyl)carbamoyl)-2-methylphenyl)(ethyl)amino)cyclohexyl)carbamate

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Chemical Property of tert-butyl ((1R,4R)-4-((5-bromo-3-(((4,6-dimethyl-2-oxo-1,2-dihydro-3-yl)methyl)carbamoyl)-2-methylphenyl)(ethyl)amino)cyclohexyl)carbamate

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Technology Process of tert-butyl ((1R,4R)-4-((5-bromo-3-(((4,6-dimethyl-2-oxo-1,2-dihydro-3-yl)methyl)carbamoyl)-2-methylphenyl)(ethyl)amino)cyclohexyl)carbamate

There total 6 articles about tert-butyl ((1R,4R)-4-((5-bromo-3-(((4,6-dimethyl-2-oxo-1,2-dihydro-3-yl)methyl)carbamoyl)-2-methylphenyl)(ethyl)amino)cyclohexyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1403258-27-4
methyl 5-bromo-3-(((trans)-4-((tert-butoxycarbonyl)amino)cyclohexyl)-(ethyl)amino)-2-methylbenzoate

: 1403258-29-6
tert-butyl ((1R,4R)-4-((5-bromo-3-(((4,6-dimethyl-2-oxo-1,2-dihydro-3-yl)methyl)carbamoyl)-2-methylphenyl)(ethyl)amino)cyclohexyl)carbamate

Guidance literature:: methyl 5-bromo-3-(((trans)-4-((tert-butoxycarbonyl)amino)cyclohexyl)-(ethyl)amino)-2-methylbenzoate; With water; sodium hydroxide; In ethanol; at 60 ℃; for 1h;

With hydrogenchloride; In water; pH=8;

With citric acid; In water; pH=6; Product distribution / selectivity;

Reference yield:

: 1975-50-4
2-methyl-3-nitrobenzic acid

: 1403258-29-6
tert-butyl ((1R,4R)-4-((5-bromo-3-(((4,6-dimethyl-2-oxo-1,2-dihydro-3-yl)methyl)carbamoyl)-2-methylphenyl)(ethyl)amino)cyclohexyl)carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; sulfuric acid / 5 h / 20 °C

2.1: sodium carbonate / N,N-dimethyl-formamide / 8 h / 60 °C

3.1: ammonium chloride; iron / ethanol; water / 7 h / 80 °C

4.1: acetic acid / methanol / 8 h / 20 °C

4.2: 0 °C

5.1: acetic acid / 1,1-dichloroethane / 0.33 h / 20 °C

5.2: 0 - 20 °C

6.1: sodium hydroxide; water / ethanol / 1 h / 60 °C

6.2: pH 6

6.3: pH 4

With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; sulfuric acid; water; iron; sodium carbonate; ammonium chloride; acetic acid; sodium hydroxide; In methanol; 1,1-dichloroethane; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 220514-28-3
5-bromo-2-methyl-3-nitrobenzoic acid methyl ester

: 1403258-29-6
tert-butyl ((1R,4R)-4-((5-bromo-3-(((4,6-dimethyl-2-oxo-1,2-dihydro-3-yl)methyl)carbamoyl)-2-methylphenyl)(ethyl)amino)cyclohexyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: ammonium chloride; iron / ethanol; water / 7 h / 80 °C

2.1: acetic acid / methanol / 8 h / 20 °C

2.2: 0 °C

3.1: acetic acid / 1,1-dichloroethane / 0.33 h / 20 °C

3.2: 0 - 20 °C

4.1: sodium hydroxide; water / ethanol / 1 h / 60 °C

4.2: pH 6

4.3: pH 4

With water; iron; ammonium chloride; acetic acid; sodium hydroxide; In methanol; 1,1-dichloroethane; ethanol; water;