(2S)-6-{(1E)-3-[(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4,5]dec-9-yl]prop-1-en-1-yl}-2'-oxo-1,1',2',3-tetrahydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridine]-5-carbonitrile

Base Information

Chemical Name:(2S)-6-{(1E)-3-[(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4,5]dec-9-yl]prop-1-en-1-yl}-2'-oxo-1,1',2',3-tetrahydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridine]-5-carbonitrile
CAS No.:1189569-41-2
Molecular Formula:C₃₄H₃₁F₂N₅O₂
Molecular Weight:579.649
Hs Code.:

(2S)-6-{(1E)-3-[(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4,5]dec-9-yl]prop-1-en-1-yl}-2'-oxo-1,1',2',3-tetrahydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridine]-5-carbonitrile

Synonyms:(2S)-6-{(1E)-3-[(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4,5]dec-9-yl]prop-1-en-1-yl}-2'-oxo-1,1',2',3-tetrahydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridine]-5-carbonitrile

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Chemical Property of (2S)-6-{(1E)-3-[(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4,5]dec-9-yl]prop-1-en-1-yl}-2'-oxo-1,1',2',3-tetrahydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridine]-5-carbonitrile

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Technology Process of (2S)-6-{(1E)-3-[(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4,5]dec-9-yl]prop-1-en-1-yl}-2'-oxo-1,1',2',3-tetrahydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridine]-5-carbonitrile

There total 16 articles about (2S)-6-{(1E)-3-[(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4,5]dec-9-yl]prop-1-en-1-yl}-2'-oxo-1,1',2',3-tetrahydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridine]-5-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1189570-11-3
(2R)-6-bromo-2'-oxo-1,1',2',3-tetrahydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridine]-5-carbonitrile

: 1189570-20-4
(8R)-9-allyl-8-(3,5-difluorophenyl)-8-methyl-6,9-diazaspiro[4.5]decan-10-one

: 1189569-41-2
(2S)-6-{(1E)-3-[(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4,5]dec-9-yl]prop-1-en-1-yl}-2'-oxo-1,1',2',3-tetrahydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridine]-5-carbonitrile

Guidance literature:: With N-Methyldicyclohexylamine; bis(tri-tert-butylphosphine)palladium⁽⁰⁾; In dimethyl amine; at 20 - 120 ℃; for 18h;

Reference yield:

: 879132-46-4
1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridine

: 1189569-41-2
(2S)-6-{(1E)-3-[(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4,5]dec-9-yl]prop-1-en-1-yl}-2'-oxo-1,1',2',3-tetrahydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridine]-5-carbonitrile

Guidance literature:: Multi-step reaction with 12 steps

1: pyridinium hydrobromide perbromide / 1,4-dioxane / 1 h / 20 °C

2: water

3: ammonium chloride; zinc / tetrahydrofuran; water / 3 h

4: caesium carbonate / N,N-dimethyl-formamide / 18 h

5: hydrogen / palladium 10% on activated carbon / ethanol / 18 h / 760.05 Torr

6: chloroform / 17 h / Reflux

7: hydrogenchloride / methanol

8: ethylenediamine; sodium hydroxide / methanol / 0.5 h / pH 10

9: N-iodo-succinimide / tetrahydrofuran / 18 h / 20 °C

10: zinc / bis(tri-tert-butylphosphine)palladium⁽⁰⁾ / N,N-dimethyl-formamide / 2 h / 20 - 80 °C

11: hydrogen bromide; sodium nitrite / copper(I) bromide / water / 1 h / 0 - 20 °C / Cooling

12: N-Methyldicyclohexylamine / bis(tri-tert-butylphosphine)palladium⁽⁰⁾ / dimethyl amine / 18 h / 20 - 120 °C

With hydrogenchloride; N-iodo-succinimide; N-Methyldicyclohexylamine; water; hydrogen bromide; hydrogen; pyridinium hydrobromide perbromide; ammonium chloride; caesium carbonate; ethylenediamine; sodium hydroxide; zinc; sodium nitrite; bis(tri-tert-butylphosphine)palladium⁽⁰⁾; palladium 10% on activated carbon; copper(I) bromide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; chloroform; water; dimethyl amine; N,N-dimethyl-formamide;

Reference yield:

: 271-63-6
7-Azaindole

: 1189569-41-2
(2S)-6-{(1E)-3-[(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4,5]dec-9-yl]prop-1-en-1-yl}-2'-oxo-1,1',2',3-tetrahydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridine]-5-carbonitrile

Guidance literature:: Multi-step reaction with 13 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1.42 h / 0 °C

1.2: 1.25 h / 10 °C

2.1: pyridinium hydrobromide perbromide / 1,4-dioxane / 1 h / 20 °C

3.1: water

4.1: ammonium chloride; zinc / tetrahydrofuran; water / 3 h

5.1: caesium carbonate / N,N-dimethyl-formamide / 18 h

6.1: hydrogen / palladium 10% on activated carbon / ethanol / 18 h / 760.05 Torr

7.1: chloroform / 17 h / Reflux

8.1: hydrogenchloride / methanol

9.1: ethylenediamine; sodium hydroxide / methanol / 0.5 h / pH 10

10.1: N-iodo-succinimide / tetrahydrofuran / 18 h / 20 °C

11.1: zinc / bis(tri-tert-butylphosphine)palladium⁽⁰⁾ / N,N-dimethyl-formamide / 2 h / 20 - 80 °C

12.1: hydrogen bromide; sodium nitrite / copper(I) bromide / water / 1 h / 0 - 20 °C / Cooling

13.1: N-Methyldicyclohexylamine / bis(tri-tert-butylphosphine)palladium⁽⁰⁾ / dimethyl amine / 18 h / 20 - 120 °C

With hydrogenchloride; N-iodo-succinimide; N-Methyldicyclohexylamine; water; hydrogen bromide; hydrogen; pyridinium hydrobromide perbromide; sodium hydride; ammonium chloride; caesium carbonate; ethylenediamine; sodium hydroxide; zinc; sodium nitrite; bis(tri-tert-butylphosphine)palladium⁽⁰⁾; palladium 10% on activated carbon; copper(I) bromide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; chloroform; water; dimethyl amine; N,N-dimethyl-formamide; mineral oil;