1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridine

Base Information

• Chemical Name: 1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridine
• CAS No.: 879132-46-4
• Molecular Formula: C13H20N2OSi
• Molecular Weight: 248.4
• Mol file: 879132-46-4.mol

Synonyms:1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrolo-[2,3-b]pyridine;1-[(2-(trimethylsilyl)ethoxy)methyl]-1,2,4-triazol-3-amine;1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrrolo[2,3-b]pyridine;3-amino-1-(2-trimethylsilanyl-ethoxymethyl)-1H-[1,2,4]triazole;1H-1,2,4-Triazol-3-amine,1-[[2-(trimethylsilyl)ethoxy]methyl];1-[(2-(trimethylsilyl)ethoxy)methyl]-7-azaindole;

Chemical Property of 1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridine

Chemical Property:

• PSA: 27.05000
• LogP: 3.34860

Purity/Quality:

99%, ^*data from raw suppliers

1-((2-(Trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-((2-(Trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridine is used in preparation of bicyclic heteroaryl compounds as kinase inhibitors useful in treatment of kinase-mediated diseases including neuropsychiatric diseases.

Technology Process of 1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridine

There total 2 articles about 1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

7-Azaindole (271-63-6) + (2-trimethylethylsilylethoxy)methyl chloride (76513-69-4) → 1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridine (879132-46-4)

Guidance literature:

7-Azaindole; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 1.25h;

(2-trimethylethylsilylethoxy)methyl chloride; In N,N-dimethyl-formamide; mineral oil; for 1.25h;

Reference yield:

(2-trimethylethylsilylethoxy)methyl chloride (76513-69-4) → 1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridine (879132-46-4)

Guidance literature:

7-Azaindole; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 1.41667h;

(2-trimethylethylsilylethoxy)methyl chloride; In N,N-dimethyl-formamide; at 10 ℃; for 1.25h;

Reference yield: 81.0%

1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridine (879132-46-4) + iodobenzene (591-50-4) → 2-phenyl-1-[(2-(trimethylsilyl)ethoxy)methyl]-7-azaindole

Guidance literature:

With palladium(II) complex with imidazolyl carbene ligand; cesium acetate; In N,N-dimethyl acetamide; at 125 ℃; for 24h;

DOI:10.1021/ol053021c

upstream raw materials:

7-Azaindole

(2-trimethylethylsilylethoxy)methyl chloride

Downstream raw materials:

3,3-dibromo-1-{[2-(trimethylsilyl)ethoxy]methyl}-1,3-dihydro-2H-pyrrolo[2.3-b]pyridin-2-one

5-nitro-1‘-((2-(trimethylsilyl)ethoxy)methyl)-1,3-dihydrospiro[indene-2,3’-pyrrolo[2,3-b]pyridin]-2’(1’H)-one

1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one

5-bromo-1-{[2-(trimethylsilyl)ethoxy]methyl}-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one

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