(8R)-9-allyl-8-(3,5-difluorophenyl)-8-methyl-6,9-diazaspiro[4.5]decan-10-one

Base Information

Chemical Name:(8R)-9-allyl-8-(3,5-difluorophenyl)-8-methyl-6,9-diazaspiro[4.5]decan-10-one
CAS No.:1189570-20-4
Molecular Formula:C₁₈H₂₂F₂N₂O
Molecular Weight:320.382
Hs Code.:

Synonyms:(8R)-9-allyl-8-(3,5-difluorophenyl)-8-methyl-6,9-diazaspiro[4.5]decan-10-one

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Chemical Property of (8R)-9-allyl-8-(3,5-difluorophenyl)-8-methyl-6,9-diazaspiro[4.5]decan-10-one

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Technology Process of (8R)-9-allyl-8-(3,5-difluorophenyl)-8-methyl-6,9-diazaspiro[4.5]decan-10-one

There total 5 articles about (8R)-9-allyl-8-(3,5-difluorophenyl)-8-methyl-6,9-diazaspiro[4.5]decan-10-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1189569-73-0
(8R)-8-(3,5-difluorophenyl)-8-methyl-6,9-diazaspiro[4.5]decan-10-one

: 106-95-6
allyl bromide

: 1189570-20-4
(8R)-9-allyl-8-(3,5-difluorophenyl)-8-methyl-6,9-diazaspiro[4.5]decan-10-one

Guidance literature:: (8R)-8-(3,5-difluorophenyl)-8-methyl-6,9-diazaspiro[4.5]decan-10-one; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 1.5h;

allyl bromide; In N,N-dimethyl-formamide; at 20 ℃; for 18h;
DOI:10.1021/ml400199p

Reference yield:

: 957122-15-5
tert-butyl [1-(3,5-difluorophenyl)-1-methyl-2-oxoethyl]carbamate

: 1189570-20-4
(8R)-9-allyl-8-(3,5-difluorophenyl)-8-methyl-6,9-diazaspiro[4.5]decan-10-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid / methanol / 0.5 h / 20 °C

1.2: 0.5 h / pH 5

2.1: hydrogenchloride / ethyl acetate / 0.5 h / 0 °C

3.1: acetic acid / 5,5-dimethyl-1,3-cyclohexadiene / 3 h / 80 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 1.5 h / 0 - 20 °C

4.2: 18 h / 20 °C

With hydrogenchloride; sodium hydride; acetic acid; In methanol; 5,5-dimethyl-1,3-cyclohexadiene; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ml400199p

Reference yield:

: 957122-14-4
tert-butyl 2-[(tert-butoxycarbonyl)amino]-2-(3,5-difluorophenyl)propanoate

: 1189570-20-4
(8R)-9-allyl-8-(3,5-difluorophenyl)-8-methyl-6,9-diazaspiro[4.5]decan-10-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / -78 °C

2.1: acetic acid / methanol / 0.5 h / 20 °C

2.2: 0.5 h / pH 5

3.1: hydrogenchloride / ethyl acetate / 0.5 h / 0 °C

4.1: acetic acid / 5,5-dimethyl-1,3-cyclohexadiene / 3 h / 80 °C

5.1: sodium hydride / N,N-dimethyl-formamide / 1.5 h / 0 - 20 °C

5.2: 18 h / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; sodium hydride; acetic acid; In tetrahydrofuran; methanol; 5,5-dimethyl-1,3-cyclohexadiene; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ml400199p