N-Cyclohexyl-2-[(3,5-dichloropyridin-4-yl)amino]-7,7-dimethyl-7,8-dihydro-1H-furo[3,2-e]benzimidazole-5-carboxamide

Base Information

Chemical Name:N-Cyclohexyl-2-[(3,5-dichloropyridin-4-yl)amino]-7,7-dimethyl-7,8-dihydro-1H-furo[3,2-e]benzimidazole-5-carboxamide
CAS No.:1374295-92-7
Molecular Formula:C₂₃H₂₅Cl₂N₅O₂
Molecular Weight:474.39
Hs Code.:

Synonyms:N-Cyclohexyl-2-[(3,5-dichloropyridin-4-yl)amino]-7,7-dimethyl-7,8-dihydro-1H-furo[3,2-e]benzimidazole-5-carboxamide

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Chemical Property of N-Cyclohexyl-2-[(3,5-dichloropyridin-4-yl)amino]-7,7-dimethyl-7,8-dihydro-1H-furo[3,2-e]benzimidazole-5-carboxamide

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Technology Process of N-Cyclohexyl-2-[(3,5-dichloropyridin-4-yl)amino]-7,7-dimethyl-7,8-dihydro-1H-furo[3,2-e]benzimidazole-5-carboxamide

There total 17 articles about N-Cyclohexyl-2-[(3,5-dichloropyridin-4-yl)amino]-7,7-dimethyl-7,8-dihydro-1H-furo[3,2-e]benzimidazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1374298-21-1
2-[(3,5-dichloropyridin-4-yl)amino]-7,7-dimethyl-7,8-dihydro-1H-furo[3,2-e]benzimidazole-5-carboxylic acid

: 108-91-8,157973-60-9
cyclohexylamine

: 1374295-92-7
N-Cyclohexyl-2-[(3,5-dichloropyridin-4-yl)amino]-7,7-dimethyl-7,8-dihydro-1H-furo[3,2-e]benzimidazole-5-carboxamide

Guidance literature:: 2-[(3,5-dichloropyridin-4-yl)amino]-7,7-dimethyl-7,8-dihydro-1H-furo[3,2-e]benzimidazole-5-carboxylic acid; With 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In tetrahydrofuran; N,N-dimethyl-formamide; at 22 - 26 ℃; for 0.5h;

cyclohexylamine; In tetrahydrofuran; N,N-dimethyl-formamide; at 22 - 26 ℃;

Reference yield:

: 1583-58-0
2,4-difluoro-benzoic acid

: 1374295-92-7
N-Cyclohexyl-2-[(3,5-dichloropyridin-4-yl)amino]-7,7-dimethyl-7,8-dihydro-1H-furo[3,2-e]benzimidazole-5-carboxamide

Guidance literature:: Multi-step reaction with 12 steps

1.1: sulfuric acid; nitric acid / water / 14 h / 0 - 5 °C

2.1: sulfuric acid / ethanol / 24 h / Reflux

3.1: triethylamine / tetrahydrofuran / 0 - 26 °C

4.1: sodium methylate / methanol; water / 0 - 26 °C

5.1: aluminum (III) chloride / 1,2-dichloro-ethane / Reflux

6.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 80 °C

6.2: 80 °C

7.1: N,N-diethylaniline / 1.3 h / Reflux

8.1: formic acid / 100 °C

9.1: hydrogenchloride; iron / methanol; water / 1 h / 22 - 26 °C

10.1: acetonitrile / 24 h / 22 - 26 °C

10.2: 22 - 26 °C

11.1: water; sodium hydroxide / methanol / 60 °C

12.1: 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / tetrahydrofuran; N,N-dimethyl-formamide / 0.5 h / 22 - 26 °C

12.2: 22 - 26 °C

With 4-methyl-morpholine; hydrogenchloride; aluminum (III) chloride; formic acid; sulfuric acid; water; nitric acid; sodium methylate; iron; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N,N-diethylaniline; sodium hydroxide; sulfuric acid; In tetrahydrofuran; methanol; ethanol; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 153775-33-8
2,4-difluoro-5-nitro-benzoic acid

: 1374295-92-7
N-Cyclohexyl-2-[(3,5-dichloropyridin-4-yl)amino]-7,7-dimethyl-7,8-dihydro-1H-furo[3,2-e]benzimidazole-5-carboxamide

Guidance literature:: Multi-step reaction with 11 steps

1.1: sulfuric acid / ethanol / 24 h / Reflux

2.1: triethylamine / tetrahydrofuran / 0 - 26 °C

3.1: sodium methylate / methanol; water / 0 - 26 °C

4.1: aluminum (III) chloride / 1,2-dichloro-ethane / Reflux

5.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 80 °C

5.2: 80 °C

6.1: N,N-diethylaniline / 1.3 h / Reflux

7.1: formic acid / 100 °C

8.1: hydrogenchloride; iron / methanol; water / 1 h / 22 - 26 °C

9.1: acetonitrile / 24 h / 22 - 26 °C

9.2: 22 - 26 °C

10.1: water; sodium hydroxide / methanol / 60 °C

11.1: 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / tetrahydrofuran; N,N-dimethyl-formamide / 0.5 h / 22 - 26 °C

11.2: 22 - 26 °C

With 4-methyl-morpholine; hydrogenchloride; aluminum (III) chloride; formic acid; water; sodium methylate; iron; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N,N-diethylaniline; sodium hydroxide; sulfuric acid; In tetrahydrofuran; methanol; ethanol; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;