1-(3'-deoxy-5'-O-triphenylmethyl-β-D-thymidin-3'-yl)-3-(4-chloro-3-(trifluoromethyl)phenyl)thiourea

Base Information

• Chemical Name: 1-(3'-deoxy-5'-O-triphenylmethyl-β-D-thymidin-3'-yl)-3-(4-chloro-3-(trifluoromethyl)phenyl)thiourea
• CAS No.: 1219808-55-5
• Molecular Formula: C₃₇H₃₂ClF₃N₄O₄S
• Molecular Weight: 721.2

Synonyms:1-(3'-deoxy-5'-O-triphenylmethyl-β-D-thymidin-3'-yl)-3-(4-chloro-3-(trifluoromethyl)phenyl)thiourea

Chemical Property of 1-(3'-deoxy-5'-O-triphenylmethyl-β-D-thymidin-3'-yl)-3-(4-chloro-3-(trifluoromethyl)phenyl)thiourea

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Technology Process of 1-(3'-deoxy-5'-O-triphenylmethyl-β-D-thymidin-3'-yl)-3-(4-chloro-3-(trifluoromethyl)phenyl)thiourea

There total 1 articles about 1-(3'-deoxy-5'-O-triphenylmethyl-β-D-thymidin-3'-yl)-3-(4-chloro-3-(trifluoromethyl)phenyl)thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3'-amino-3'-deoxy-5'-O-triphenylmethyl-β-D-thymidine (124355-25-5) + 1-chloro-4-isothiocyanato-2-(trifluoromethyl)benzene (23163-86-2) → 1-(3'-deoxy-5'-O-triphenylmethyl-β-D-thymidin-3'-yl)-3-(4-chloro-3-(trifluoromethyl)phenyl)thiourea (1219808-55-5)

Guidance literature:

In N,N-dimethyl-formamide; at 0 - 20 ℃;

DOI:10.1021/jm901532h

Reference yield: 57.0%

1-(3'-deoxy-5'-O-triphenylmethyl-β-D-thymidin-3'-yl)-3-(4-chloro-3-(trifluoromethyl)phenyl)thiourea (1219808-55-5) → N-(3'-deoxy-5'-O-triphenylmethyl-β-D-thymidin-3'-yl)-N'-(4-chloro-3-trifluoromethylphenyl)-guanidine (1271302-24-9)

Guidance literature:

With ammonia; triethylamine; mercury dichloride; In N,N-dimethyl-formamide; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1039/c0ob00591f

Reference yield: 57.0%

1-(3'-deoxy-5'-O-triphenylmethyl-β-D-thymidin-3'-yl)-3-(4-chloro-3-(trifluoromethyl)phenyl)thiourea (1219808-55-5) + isopropylamine (75-31-0) → N-(3'-deoxy-5'-O-triphenylmethyl-β-D-thymidin-3'-yl)-N'-(4-chloro-3-trifluoromethylphenyl)-isopropylguanidine (1271302-28-3)

Guidance literature:

With triethylamine; mercury dichloride; In N,N-dimethyl-formamide; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1039/c0ob00591f

upstream raw materials:

3'-amino-3'-deoxy-5'-O-triphenylmethyl-β-D-thymidine

1-chloro-4-isothiocyanato-2-(trifluoromethyl)benzene

Downstream raw materials:

N-(3'-deoxy-β-D-thymidin-3'-yl)-N'-(4-chloro-3-trifluoromethylphenyl)-guanidine

5-(3'-amino-3'-deoxy-5'-O-triphenylmethyl-β-D-thymidin-3'N-yl)-1-(4-chloro-3-trifluoromethylphenyl)-tetrazole

5-(3'-amino-3'-deoxy-β-D-thymidin-3'N-yl)-1-(4-chloro-3-trifluoromethylphenyl)-tetrazole

N-(3'-deoxy-β-D-thymidin-3'-yl)-N'-(4-chloro-3-trifluoromethylphenyl)-benzylguanidine

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