N-(3'-deoxy-5'-O-triphenylmethyl-β-D-thymidin-3'-yl)-N'-(4-chloro-3-trifluoromethylphenyl)-isopropylguanidine

Base Information

• Chemical Name: N-(3'-deoxy-5'-O-triphenylmethyl-β-D-thymidin-3'-yl)-N'-(4-chloro-3-trifluoromethylphenyl)-isopropylguanidine
• CAS No.: 1271302-28-3
• Molecular Formula: C₄₀H₃₉ClF₃N₅O₄
• Molecular Weight: 746.229

Synonyms:N-(3'-deoxy-5'-O-triphenylmethyl-β-D-thymidin-3'-yl)-N'-(4-chloro-3-trifluoromethylphenyl)-isopropylguanidine

Chemical Property of N-(3'-deoxy-5'-O-triphenylmethyl-β-D-thymidin-3'-yl)-N'-(4-chloro-3-trifluoromethylphenyl)-isopropylguanidine

Chemical Property:

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Technology Process of N-(3'-deoxy-5'-O-triphenylmethyl-β-D-thymidin-3'-yl)-N'-(4-chloro-3-trifluoromethylphenyl)-isopropylguanidine

There total 3 articles about N-(3'-deoxy-5'-O-triphenylmethyl-β-D-thymidin-3'-yl)-N'-(4-chloro-3-trifluoromethylphenyl)-isopropylguanidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

1-(3'-deoxy-5'-O-triphenylmethyl-β-D-thymidin-3'-yl)-3-(4-chloro-3-(trifluoromethyl)phenyl)thiourea (1219808-55-5) + isopropylamine (75-31-0) → N-(3'-deoxy-5'-O-triphenylmethyl-β-D-thymidin-3'-yl)-N'-(4-chloro-3-trifluoromethylphenyl)-isopropylguanidine (1271302-28-3)

Guidance literature:

With triethylamine; mercury dichloride; In N,N-dimethyl-formamide; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1039/c0ob00591f

Reference yield:

3'-amino-3'-deoxy-5'-O-triphenylmethyl-β-D-thymidine (124355-25-5) → N-(3'-deoxy-5'-O-triphenylmethyl-β-D-thymidin-3'-yl)-N'-(4-chloro-3-trifluoromethylphenyl)-isopropylguanidine (1271302-28-3)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

2: triethylamine; mercury dichloride / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

With triethylamine; mercury dichloride; In N,N-dimethyl-formamide;

DOI:10.1039/c0ob00591f

Reference yield:

1-chloro-4-isothiocyanato-2-(trifluoromethyl)benzene (23163-86-2) → N-(3'-deoxy-5'-O-triphenylmethyl-β-D-thymidin-3'-yl)-N'-(4-chloro-3-trifluoromethylphenyl)-isopropylguanidine (1271302-28-3)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

2: triethylamine; mercury dichloride / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

With triethylamine; mercury dichloride; In N,N-dimethyl-formamide;

DOI:10.1039/c0ob00591f

upstream raw materials:

1-(3'-deoxy-5'-O-triphenylmethyl-β-D-thymidin-3'-yl)-3-(4-chloro-3-(trifluoromethyl)phenyl)thiourea

isopropylamine

3'-amino-3'-deoxy-5'-O-triphenylmethyl-β-D-thymidine

1-chloro-4-isothiocyanato-2-(trifluoromethyl)benzene

Downstream raw materials:

N-(3'-deoxy-β-D-thymidin-3'-yl)-N'-(4-chloro-3-trifluoromethylphenyl)-isopropylguanidine

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