(1R,2S,3R,6S)-2-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-6-isopropyl-3-methyl-cyclohexanol

Base Information

Chemical Name:(1R,2S,3R,6S)-2-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-6-isopropyl-3-methyl-cyclohexanol
CAS No.:213826-08-5
Molecular Formula:C₁₈H₃₈O₂Si
Molecular Weight:314.584
Hs Code.:

Synonyms:(1R,2S,3R,6S)-2-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-6-isopropyl-3-methyl-cyclohexanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,2S,3R,6S)-2-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-6-isopropyl-3-methyl-cyclohexanol

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Technology Process of (1R,2S,3R,6S)-2-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-6-isopropyl-3-methyl-cyclohexanol

There total 8 articles about (1R,2S,3R,6S)-2-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-6-isopropyl-3-methyl-cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: (2S,3R,6S)-2-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-6-isopropyl-3-methyl-cyclohexanone

: 213826-08-5
(1R,2S,3R,6S)-2-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-6-isopropyl-3-methyl-cyclohexanol

Guidance literature:: With L-Selectride; In tetrahydrofuran;
DOI:10.1246/cl.1998.739

Reference yield:

: 2216-51-5
(-)-menthol

: 213826-08-5
(1R,2S,3R,6S)-2-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-6-isopropyl-3-methyl-cyclohexanol

Guidance literature:: Multi-step reaction with 8 steps

2: TsN₃, Et₃N

3: Rh₂(OAc)4

4: 1.) MeONa, 2.) p-TsOH / 1.) MeOH, 2.) CH₂Cl₂

5: 90 percent / LiAlH₄ / diethyl ether

6: 91 percent / imidazole / dimethylformamide

7: 83 percent / Dess-Martin periodinane / CH₂Cl₂

8: 89 percent / L-Selectride / tetrahydrofuran

With 1H-imidazole; dirhodium tetraacetate; lithium aluminium tetrahydride; 4-toluenesulfonyl azide; sodium methylate; L-Selectride; Dess-Martin periodane; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1246/cl.1998.739

Reference yield:

: 127236-74-2
(1R,2S,5R)-(-)-menthyl diazoacetoacetate

: 213826-08-5
(1R,2S,3R,6S)-2-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-6-isopropyl-3-methyl-cyclohexanol

Guidance literature:: Multi-step reaction with 6 steps

1: Rh₂(OAc)4

2: 1.) MeONa, 2.) p-TsOH / 1.) MeOH, 2.) CH₂Cl₂

3: 90 percent / LiAlH₄ / diethyl ether

4: 91 percent / imidazole / dimethylformamide

5: 83 percent / Dess-Martin periodinane / CH₂Cl₂

6: 89 percent / L-Selectride / tetrahydrofuran

With 1H-imidazole; dirhodium tetraacetate; lithium aluminium tetrahydride; sodium methylate; L-Selectride; Dess-Martin periodane; toluene-4-sulfonic acid; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1246/cl.1998.739