(Z)-2-[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]-1-{4-[4-(2-cyclohexyl-N-methoxyethanimidoyl)-1,3-thiazol-2-yl]piperidin-1-yl}ethanone

Base Information

Chemical Name:(Z)-2-[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]-1-{4-[4-(2-cyclohexyl-N-methoxyethanimidoyl)-1,3-thiazol-2-yl]piperidin-1-yl}ethanone
CAS No.:1345958-33-9
Molecular Formula:C₂₄H₃₁F₄N₅O₂S
Molecular Weight:529.602
Hs Code.:

Synonyms:(Z)-2-[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]-1-{4-[4-(2-cyclohexyl-N-methoxyethanimidoyl)-1,3-thiazol-2-yl]piperidin-1-yl}ethanone

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Chemical Property of (Z)-2-[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]-1-{4-[4-(2-cyclohexyl-N-methoxyethanimidoyl)-1,3-thiazol-2-yl]piperidin-1-yl}ethanone

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Technology Process of (Z)-2-[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]-1-{4-[4-(2-cyclohexyl-N-methoxyethanimidoyl)-1,3-thiazol-2-yl]piperidin-1-yl}ethanone

There total 5 articles about (Z)-2-[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]-1-{4-[4-(2-cyclohexyl-N-methoxyethanimidoyl)-1,3-thiazol-2-yl]piperidin-1-yl}ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 512809-60-8
[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetic acid

: 4-[4-(2-cyclohexyl-N-methoxyethanimidoyl)-1,3-thiazol-2-yl]piperidinium chloride

: 1345958-33-9
(Z)-2-[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]-1-{4-[4-(2-cyclohexyl-N-methoxyethanimidoyl)-1,3-thiazol-2-yl]piperidin-1-yl}ethanone

Guidance literature:: With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In dichloromethane; at 20 ℃; for 3h;

Reference yield:

: 365413-00-9
4-(4-carboxy-thiazol-2-yl)-piperidine-1-carboxylic acid tert-butyl ester

: 1345958-33-9
(Z)-2-[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]-1-{4-[4-(2-cyclohexyl-N-methoxyethanimidoyl)-1,3-thiazol-2-yl]piperidin-1-yl}ethanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / dichloromethane / 0.17 h / 20 °C

1.2: 20 °C

2.1: diethyl ether; tetrahydrofuran / 2 h / -78 - 20 °C / Inert atmosphere

3.1: ethanol / 24 h / 20 - 50 °C

4.1: hydrogenchloride / 1,4-dioxane / 0 - 20 °C / Inert atmosphere

5.1: dmap; triethylamine; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 3 h / 20 °C

With hydrogenchloride; dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; dichloromethane;

Reference yield:

: 1345958-89-5
tert-butyl 4-{4-[methoxy(methyl)carbamoyl]-1,3-thiazol-2-yl}piperidine-1-carboxylate

: 1345958-33-9
(Z)-2-[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]-1-{4-[4-(2-cyclohexyl-N-methoxyethanimidoyl)-1,3-thiazol-2-yl]piperidin-1-yl}ethanone

Guidance literature:: Multi-step reaction with 4 steps

1: diethyl ether; tetrahydrofuran / 2 h / -78 - 20 °C / Inert atmosphere

2: ethanol / 24 h / 20 - 50 °C

3: hydrogenchloride / 1,4-dioxane / 0 - 20 °C / Inert atmosphere

4: dmap; triethylamine; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 3 h / 20 °C

With hydrogenchloride; dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; dichloromethane;