methyl 2-{4-[3-(4-fluorophenoxy)-5-{[(4-hydroxy-4-isobutyl-1-piperidinyl)carbonyl]amino}phenoxy]phenyl}-2-methylpropanoate

Base Information

Chemical Name:methyl 2-{4-[3-(4-fluorophenoxy)-5-{[(4-hydroxy-4-isobutyl-1-piperidinyl)carbonyl]amino}phenoxy]phenyl}-2-methylpropanoate
CAS No.:1428901-10-3
Molecular Formula:C₃₃H₃₉FN₂O₆
Molecular Weight:578.681
Hs Code.:

Synonyms:methyl 2-{4-[3-(4-fluorophenoxy)-5-{[(4-hydroxy-4-isobutyl-1-piperidinyl)carbonyl]amino}phenoxy]phenyl}-2-methylpropanoate

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Chemical Property of methyl 2-{4-[3-(4-fluorophenoxy)-5-{[(4-hydroxy-4-isobutyl-1-piperidinyl)carbonyl]amino}phenoxy]phenyl}-2-methylpropanoate

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Technology Process of methyl 2-{4-[3-(4-fluorophenoxy)-5-{[(4-hydroxy-4-isobutyl-1-piperidinyl)carbonyl]amino}phenoxy]phenyl}-2-methylpropanoate

There total 6 articles about methyl 2-{4-[3-(4-fluorophenoxy)-5-{[(4-hydroxy-4-isobutyl-1-piperidinyl)carbonyl]amino}phenoxy]phenyl}-2-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1339651-90-9
4-isobutyl-4-piperidinol

: 1428901-09-0
methyl 2-{4-[3-(4-fluorophenoxy)-5-{[(2,2,2-trichloroethoxy)carbonyl]amino}phenoxy]phenyl}-2-methylpropanoate

: 1428901-10-3
methyl 2-{4-[3-(4-fluorophenoxy)-5-{[(4-hydroxy-4-isobutyl-1-piperidinyl)carbonyl]amino}phenoxy]phenyl}-2-methylpropanoate

Guidance literature:: 4-isobutyl-4-piperidinol; methyl 2-{4-[3-(4-fluorophenoxy)-5-{[(2,2,2-trichloroethoxy)carbonyl]amino}phenoxy]phenyl}-2-methylpropanoate; In N,N-dimethyl acetamide; at 90 ℃; for 2h; Inert atmosphere;

4-isobutyl-4-piperidinol; With N-ethyl-N,N-diisopropylamine; for 2h;

Reference yield:

: 1428901-08-9
methyl 2-{4-[3-amino-5-(4-fluorophenoxy)phenoxy]phenyl}-2-methylpropanoate

: 1428901-10-3
methyl 2-{4-[3-(4-fluorophenoxy)-5-{[(4-hydroxy-4-isobutyl-1-piperidinyl)carbonyl]amino}phenoxy]phenyl}-2-methylpropanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydrogencarbonate / ethyl acetate / 1.25 h / 0 - 20 °C / Inert atmosphere

2.1: N,N-dimethyl acetamide / 2 h / 90 °C / Inert atmosphere

2.2: 2 h

With sodium hydrogencarbonate; In N,N-dimethyl acetamide; ethyl acetate;

Reference yield:

: 123342-40-5
methyl 2-(4-hydroxyphenyl)-2-methylpropanoate

: 1428901-10-3
methyl 2-{4-[3-(4-fluorophenoxy)-5-{[(4-hydroxy-4-isobutyl-1-piperidinyl)carbonyl]amino}phenoxy]phenyl}-2-methylpropanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium phosphate / N,N-dimethyl acetamide / 6.5 h / 70 °C / Inert atmosphere

2.1: potassium phosphate / N,N-dimethyl acetamide / 10 h / 100 °C / Inert atmosphere

3.1: hydrogen; 5%-palladium/activated carbon / methanol; ethyl acetate / 3 h / 20 °C / Inert atmosphere

4.1: sodium hydrogencarbonate / ethyl acetate / 1.25 h / 0 - 20 °C / Inert atmosphere

5.1: N,N-dimethyl acetamide / 2 h / 90 °C / Inert atmosphere

5.2: 2 h

With potassium phosphate; 5%-palladium/activated carbon; hydrogen; sodium hydrogencarbonate; In methanol; N,N-dimethyl acetamide; ethyl acetate;