methyl 2-{4-[3-amino-5-(4-fluorophenoxy)phenoxy]phenyl}-2-methylpropanoate

Base Information

Chemical Name:methyl 2-{4-[3-amino-5-(4-fluorophenoxy)phenoxy]phenyl}-2-methylpropanoate
CAS No.:1428901-08-9
Molecular Formula:C₂₃H₂₂FNO₄
Molecular Weight:395.43
Hs Code.:

Synonyms:methyl 2-{4-[3-amino-5-(4-fluorophenoxy)phenoxy]phenyl}-2-methylpropanoate

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Chemical Property of methyl 2-{4-[3-amino-5-(4-fluorophenoxy)phenoxy]phenyl}-2-methylpropanoate

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Technology Process of methyl 2-{4-[3-amino-5-(4-fluorophenoxy)phenoxy]phenyl}-2-methylpropanoate

There total 4 articles about methyl 2-{4-[3-amino-5-(4-fluorophenoxy)phenoxy]phenyl}-2-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1428901-07-8
methyl 2-{4-[3-(4-fluorophenoxy)-5-nitrophenoxy]phenyl}-2-methylpropanoate

: 1428901-08-9
methyl 2-{4-[3-amino-5-(4-fluorophenoxy)phenoxy]phenyl}-2-methylpropanoate

Guidance literature:: With 5%-palladium/activated carbon; hydrogen; In methanol; at 20 ℃;
DOI:10.1016/j.bmcl.2016.01.031

Reference yield:

: 1428901-06-7
methyl 2-[4-(3-fluoro-5-nitrophenoxy)phenyl]-2-methylpropanoate

: 1428901-08-9
methyl 2-{4-[3-amino-5-(4-fluorophenoxy)phenoxy]phenyl}-2-methylpropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium phosphate / N,N-dimethyl acetamide / 10 h / 100 °C / Inert atmosphere

2: hydrogen; 5%-palladium/activated carbon / methanol; ethyl acetate / 3 h / 20 °C / Inert atmosphere

With potassium phosphate; 5%-palladium/activated carbon; hydrogen; In methanol; N,N-dimethyl acetamide; ethyl acetate;

Reference yield:

: 109492-91-3
methyl 2-[4-(benzyloxy)phenyl]-2-methylpropanoate

: 1428901-08-9
methyl 2-{4-[3-amino-5-(4-fluorophenoxy)phenoxy]phenyl}-2-methylpropanoate

Guidance literature:: Multi-step reaction with 4 steps

1: palladium on carbon; hydrogen / methanol; ethyl acetate / 4 h / 20 °C / Inert atmosphere

2: potassium phosphate / N,N-dimethyl acetamide / 6.5 h / 70 °C / Inert atmosphere

3: potassium phosphate / N,N-dimethyl acetamide / 10 h / 100 °C / Inert atmosphere

4: hydrogen; 5%-palladium/activated carbon / methanol; ethyl acetate / 3 h / 20 °C / Inert atmosphere

With potassium phosphate; 5%-palladium/activated carbon; palladium on carbon; hydrogen; In methanol; N,N-dimethyl acetamide; ethyl acetate;