Benzeneacetic acid, a-Methoxy-a-(trifluoroMethyl)-, Methyl ester, (S)-

Base Information

• Chemical Name: Benzeneacetic acid, a-Methoxy-a-(trifluoroMethyl)-, Methyl ester, (S)-
• CAS No.: 26164-19-2
• Molecular Formula: C₁₁H₁₁F₃O₃
• Molecular Weight: 248.202
• Mol file: 26164-19-2.mol

Synonyms:Methyl (S)-2-methoxy-2-phenyl-3,3,3-trifluoropropionate

Chemical Property of Benzeneacetic acid, a-Methoxy-a-(trifluoroMethyl)-, Methyl ester, (S)-

Chemical Property:

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Technology Process of Benzeneacetic acid, a-Methoxy-a-(trifluoroMethyl)-, Methyl ester, (S)-

There total 9 articles about Benzeneacetic acid, a-Methoxy-a-(trifluoroMethyl)-, Methyl ester, (S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methanol (67-56-1) + (S)-Mosher acid (17257-71-5,20445-31-2,56135-03-6,81655-41-6) → Methyl (S)-2-methoxy-2-phenyl-3,3,3-trifluoropropionate (26164-19-2)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 3h;

Reference yield: 48.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + N-(benzyloxycarbonyl)-D-serine-β-lactone (98632-91-8) + potassium salt of (S)-2-methoxy-2-(trifluoromethyl)-phenylacetate → Methyl (S)-2-methoxy-2-phenyl-3,3,3-trifluoropropionate (26164-19-2) + (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-2-benzyloxycarbonylamino-2-methoxycarbonyl-ethyl ester

Guidance literature:

Yield given. Multistep reaction; 1.) DMF, 18 h, 3 deg C, 2.) ether;

DOI:10.1021/ja00249a031

Reference yield: 48.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + ((S)-2-Oxo-oxetan-3-yl)-carbamic acid benzyl ester (26054-60-4) + potassium salt of (S)-2-methoxy-2-(trifluoromethyl)-phenylacetate → Methyl (S)-2-methoxy-2-phenyl-3,3,3-trifluoropropionate (26164-19-2) + (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-2-benzyloxycarbonylamino-2-methoxycarbonyl-ethyl ester

Guidance literature:

Yield given. Multistep reaction; 1.) DMF, 18 h, 3 deg C, 2.) ether;

DOI:10.1021/ja00249a031

upstream raw materials:

(S)-3,3,3-Trifluoro-2-hydroxy-2-phenyl-propionic acid methyl ester

methyl iodide

diazomethane

((S)-2-Oxo-oxetan-3-yl)-carbamic acid benzyl ester

Downstream raw materials:

(S)-Mosher acid

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