N-[2-(2,2-Dimethoxy-ethyl)-phenyl]-4-(4-methoxy-phenoxy)-butyramide

Base Information

• Chemical Name: N-[2-(2,2-Dimethoxy-ethyl)-phenyl]-4-(4-methoxy-phenoxy)-butyramide
• CAS No.: 201486-48-8
• Molecular Formula: C₂₁H₂₇NO₅
• Molecular Weight: 373.449
• Mol file: 201486-48-8.mol

Synonyms:N-[2-(2,2-Dimethoxy-ethyl)-phenyl]-4-(4-methoxy-phenoxy)-butyramide

Chemical Property of N-[2-(2,2-Dimethoxy-ethyl)-phenyl]-4-(4-methoxy-phenoxy)-butyramide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[2-(2,2-Dimethoxy-ethyl)-phenyl]-4-(4-methoxy-phenoxy)-butyramide

There total 7 articles about N-[2-(2,2-Dimethoxy-ethyl)-phenyl]-4-(4-methoxy-phenoxy)-butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

4-(4-Methoxyphenoxy)butyric Acid (55579-99-2) + 2-(2,2-dimethoxyethyl)-benzeneamine (150760-45-5) → N-[2-(2,2-Dimethoxy-ethyl)-phenyl]-4-(4-methoxy-phenoxy)-butyramide (201486-48-8)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; for 1h; Ambient temperature;

DOI:10.1016/S0040-4039(97)10491-9

Reference yield:

(2-nitrophenyl)acetaldehyde (1969-73-9) → N-[2-(2,2-Dimethoxy-ethyl)-phenyl]-4-(4-methoxy-phenoxy)-butyramide (201486-48-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 2.) camphorsulfonic acid / 1.) MeOH, CH₂Cl₂, room temp., 30 min; 2.) MeOH, CH₂Cl₂, room temp., 75 min

2: 97 percent / H₂ / Pd/C / ethanol / Ambient temperature

3: 88 percent / DCC, DMAP / CH₂Cl₂ / 1 h / Ambient temperature

With dmap; camphor-10-sulfonic acid; hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In ethanol; dichloromethane;

DOI:10.1016/S0040-4039(97)10491-9

Reference yield:

1-methyl-2-nitrobenzene (88-72-2) → N-[2-(2,2-Dimethoxy-ethyl)-phenyl]-4-(4-methoxy-phenoxy)-butyramide (201486-48-8)

Guidance literature:

Multi-step reaction with 4 steps

1: dimethylformamide / Heating

2: camphorsulfonic acid / 9 h / Heating

3: 97 percent / H₂ / Pd/C / ethanol / Ambient temperature

4: 88 percent / DCC, DMAP / CH₂Cl₂ / 1 h / Ambient temperature

With dmap; camphor-10-sulfonic acid; hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(97)10491-9

upstream raw materials:

4-(4-Methoxyphenoxy)butyric Acid

2-(2,2-dimethoxyethyl)-benzeneamine

(2-nitrophenyl)acetaldehyde

1-methyl-2-nitrobenzene

Downstream raw materials:

1-Indol-1-yl-4-(4-methoxy-phenoxy)-butan-1-ol

1-Indol-1-yl-4-(4-methoxy-phenoxy)-butan-1-one