1969-73-9

Usage

InChI:InChI=1/C8H7NO3/c10-6-5-7-3-1-2-4-8(7)9(11)12/h1-4,6H,5H2

Upstream product

• 20973-67-5 N,N-dimethyl-2-(2-nitrophenyl)ethenylamine 
• 540-80-7 tert.-butylnitrite 
• 579-71-5 2-nitrostyrene 
• 109-95-5 ethyl nitrite 
• 79844-32-9 2-nitro-β-acetoxystyrene 
• 3740-52-1 2-(2-nitrophenyl)acetic acid 
• 7664-93-9 sulfuric acid 
• 15582-86-2 methyl o-nitrostyrylcarbamate 
• 14527-90-3 2-nitroaniline hydrochloride 
• 88-74-4 2-nitro-aniline 
• 109-92-2 ethyl vinyl ether 
• 610-33-3 (2-nitro-phenyl)-glyoxylic acid 
• 88-72-2 1-methyl-2-nitrobenzene 
• 612-41-9 2-nitrocinnamic acid 

Downstream Products

• 1969-72-8 (2-nitrophenyl)acetone 
• 271-26-1 3H-indole 
• 7479-22-3 3,3'-(o-nitrophenethylidene)di-indole 
• 117768-67-9 2,3'-(o-nitrophenethylidene)di-indole 
• 79844-33-0 2-(2-nitrophenyl)acetaldehyde dimethyl acetal 
• 502844-98-6 C₁₂H₁₃NO₄ 
• 33588-64-6 ethyl 2-(1H-indol-2-yl)acetate 
• 201486-48-8 N-[2-(2,2-Dimethoxy-ethyl)-phenyl]-4-(4-methoxy-phenoxy)-butyramide 
• 201486-49-9 N-[2-(2,2-Dimethoxy-ethyl)-phenyl]-2,4-dimethoxy-benzamide 
• 201486-60-4 1-Indol-1-yl-4-(4-methoxy-phenoxy)-butan-1-ol 
• 201486-52-4 1-Indol-1-yl-4-(4-methoxy-phenoxy)-butan-1-one 
• 201486-50-2 (E)-N-[2-(2,2-Dimethoxy-ethyl)-phenyl]-3-phenyl-acrylamide 
• 201486-51-3 Furan-2-carboxylic acid [2-(2,2-dimethoxy-ethyl)-phenyl]-amide 
• 201486-54-6 (2,4-Dimethoxy-phenyl)-indol-1-yl-methanone 

Relevant academic research and scientific papers

Exploring the Potential of 2-(2-Nitrophenyl)ethyl-Caged N-Hydroxysulfonamides for the Photoactivated Release of Nitroxyl (HNO)

The emergence of nitroxyl (HNO) as a biological signaling molecule is attracting increasing attention. HNO-based prodrugs show considerable potential in treating congestive heart failure, with HNO reacting rapidly with metal centers and protein-bound and free thiols. A new class of 2-(2-nitrophenyl)ethyl (2-NPE)-photocaged N-hydroxysulfonamides has been developed, and the mechanisms of photodecomposition have been investigated. Three photodecomposition pathways are observed: The desired concomitant C-O/N-S bond cleavage to generate HNO, sulfinate, and 2-nitrostyrene, C-O bond cleavage to give the parent sulfohydroxamic acid and 2-nitrostyrene, and O-N bond cleavage to release a sulfonamide and 2-nitrophenylacetaldehyde. Laser flash photolysis experiments provide support for a Norrish type II mechanism involving 1,5-hydrogen atom abstraction to generate an aci-nitro species. A mechanism is proposed in which the (Z)-aci-nitro intermediate undergoes either C-O bond cleavage to release RSO2NHO(H), concerted C-O/N-S bond cleavage to generate sulfinate and HNO, or isomerization to the (E)-isomer prior to O-N bond cleavage. The pKa of the N(H) of the N-hydroxysulfonamide plays a key role in determining whether C-O or concerted C-O/N-S bond cleavage occurs. Deprotonating this site favors the desired C-O/N-S bond cleavage at the expense of an increased level of undesired O-N bond cleavage. Triplet state quenchers have no effect on the observed photoproducts.

Synthesis method of phenylacetaldehyde derivative

The present invention discloses a synthesis method of phenylacetaldehyde derivative, a benzaldehyde derivative is adopted as a raw material, an intermediate 2-methoxyvinylphenyl derivative is obtained through synthesis, then the phenylacetaldehyde derivative is obtained through synthesis, and the substituent group R of the benzaldehyde derivative includes but is not limited to m-methyl, m-ethyl, m-nitrile group, p-methyl, o-methyl, o-nitro and 2, 6-dimethyl. The synthesis process is simple, synthesis conditions are mild, post-treatment is relatively simple, and industrial production is easy; the universality is good, and substrates with different functional groups are compatible; the yield is considerable, part of compounds are almost quantitatively converted, and the requirement of atom economy is met.

4H-PYRROLO[3,2-C]PYRIDIN-4-ONE DERIVATIVES

Compounds of formula (I) for use in the treatment or prophylaxis of a disease, which is a hyperproliferative disease and/or a disorder responsive to induction of cell death, selected from a haematological tumour, a solid tumour and/or metastases thereof, said tumour harbouring a mutant EGFR with exon 19 or 21 mutations, and their use as pharmaceuticals.

4H-PYRROLO[3,2-C]PYRIDIN-4-ONE DERIVATIVES

Compounds of formula (I) processes for their production and their use as pharmaceuticals.

Synthetic process of aromatic acetaldehyde compound

The invention provides a synthetic process of an aromatic acetaldehyde compound; the synthetic method includes forming a mixed solution via starting material A with N,N-dimethylformamide dimethyl acetal; continuously feeding the mixed solution into a continuous reactor to carry out enamination reaction to obtain enamide B, and discharging the enamide B from the continuous reactor during enamination reaction; preparing aromatic acetaldehyde compound C with the enamide B, wherein the starting material A has a structural formula shown as formula (1), the enamide B has a structural formula shown as formula (2), and the aromatic acetaldehyde compound C has a structural formula shown as formula (3). By continuously feeding the mixed solution of reaction materials into the reactor to carry out enamination reaction, enamination reaction is continuously performed; continuous production of aromatic acetaldehyde compounds is achieved, reaction time is shortened, and reaction efficiency is improved.

Synthesis of indolines via a SmI2 promoted domino nitro reduction-intramolecular aza-Michael reaction

A simple and straightforward synthesis of substituted indolines based on a domino nitro reduction intramolecular aza-Michael reaction is described. The reaction employs Samarium diiodide under mild conditions for the addition of dibromoacetic acid to substituted 2-(2-nitrophenyl) acetaldehyde derivatives and their subsequent cyclization upon nitro group reduction to provide corresponding indoline heterocycles in good yields. This "one pot" strategy also permitted the expeditious synthesis of a 1,2,3,4-tetrahydroquinoline, whereas the seven-membered 2,3,4,5-tetrahydrobenzoazepines compounds were not formed under these reaction conditions.

Facile synthesis of indolines by a tandem nitro-reduction Aza Michael addition reaction

A diverse array of substrates are conveniently prepared by coupling diazonium salts to ethyl vinyl ether and subjecting the resultant aldehyde intermediate to a Wittig reaction to provide α,β-unsaturated esters with only one purification step. The cyclisation of 4-aryl-but-2-enoates is carried out in the presence of stoichiometric amounts of SnCl 22H2O and thus this one-pot strategy also permitted the expeditious synthesis of indolines in good yield. The Japan Institute of Heterocyclic Chemistry.

Continuous-flow synthesis of monoarylated acetaldehydes using aryldiazonium salts

Anilines and ethyl vinyl ether can be used as precursors for a process that is the synthetic equivalent of the α-arylation of acetaldehyde enolate. The reaction manifests a high level of functional group compatibility, allowing the ready preparation of a number of synthetically valuable compounds.

An unusual route to a quinoline 1-oxide via intramolecular addition of an enolate to an aromatic nitro group

A mixture of ethyl 4-(2-nitrophenyl)butenoates undergoes an unusual intramolecular cyclisation in the presence of a catalytic amount of potassium tert-butoxide. 2011 · Copyright by Walter de Gruyter.