1969-73-9

Usage

InChI:InChI=1/C8H7NO3/c10-6-5-7-3-1-2-4-8(7)9(11)12/h1-4,6H,5H2

Upstream product

• 20973-67-5 N,N-dimethyl-2-(2-nitrophenyl)ethenylamine 
• 540-80-7 tert.-butylnitrite 
• 579-71-5 2-nitrostyrene 
• 79844-32-9 2-nitro-β-acetoxystyrene 
• 3740-52-1 2-(2-nitrophenyl)acetic acid 
• 7664-93-9 sulfuric acid 
• 15582-86-2 methyl o-nitrostyrylcarbamate 
• 14527-90-3 2-nitroaniline hydrochloride 
• 88-72-2 1-methyl-2-nitrobenzene 
• 108-05-4 vinyl acetate 
• 119-66-4 2-nitrobenzenediazonium chloride 
• 88-74-4 2-nitro-aniline 
• 109-92-2 ethyl vinyl ether 
• 610-33-3 (2-nitro-phenyl)-glyoxylic acid 

Downstream Products

• 1969-72-8 (2-nitrophenyl)acetone 
• 7479-22-3 3,3'-(o-nitrophenethylidene)di-indole 
• 117768-67-9 2,3'-(o-nitrophenethylidene)di-indole 
• 20973-92-6 o-nitrophenylacetaldehyde 2,4-dinitrophenylhydrazone 
• 79844-33-0 2-(2-nitrophenyl)acetaldehyde dimethyl acetal 
• 6941-73-7 2-(2,2-di(1H-indol-3-yl)ethyl)aniline 
• 6548-01-2 3,3'-(o-acetamidophenethylidene)di-indole 
• 117768-68-0 1'-acetyl-2,3'-(o-diacetylaminophenethylidene)di-indole 
• 65439-79-4 3-formyl-2,3'-(o-acetamidophenethylidene)di-indole 
• 65439-77-2 2,3'-(o-aminophenethylidene)di-indole 
• 65439-78-3 2,3'-(o-acetamidophenethylidene)di-indole 
• 1233823-81-8 (S)-(+)-methyl 6-methyl-4-(2-nitrophenyl)-1,4-dihydropyridazine-5-carboxylate 
• 502844-98-6 C₁₂H₁₃NO₄ 
• 33588-64-6 ethyl 2-(1H-indol-2-yl)acetate 

Relevant academic research and scientific papers

Synthesis method of phenylacetaldehyde derivative

The present invention discloses a synthesis method of phenylacetaldehyde derivative, a benzaldehyde derivative is adopted as a raw material, an intermediate 2-methoxyvinylphenyl derivative is obtained through synthesis, then the phenylacetaldehyde derivative is obtained through synthesis, and the substituent group R of the benzaldehyde derivative includes but is not limited to m-methyl, m-ethyl, m-nitrile group, p-methyl, o-methyl, o-nitro and 2, 6-dimethyl. The synthesis process is simple, synthesis conditions are mild, post-treatment is relatively simple, and industrial production is easy; the universality is good, and substrates with different functional groups are compatible; the yield is considerable, part of compounds are almost quantitatively converted, and the requirement of atom economy is met.

Exploring the Potential of 2-(2-Nitrophenyl)ethyl-Caged N-Hydroxysulfonamides for the Photoactivated Release of Nitroxyl (HNO)

The emergence of nitroxyl (HNO) as a biological signaling molecule is attracting increasing attention. HNO-based prodrugs show considerable potential in treating congestive heart failure, with HNO reacting rapidly with metal centers and protein-bound and free thiols. A new class of 2-(2-nitrophenyl)ethyl (2-NPE)-photocaged N-hydroxysulfonamides has been developed, and the mechanisms of photodecomposition have been investigated. Three photodecomposition pathways are observed: The desired concomitant C-O/N-S bond cleavage to generate HNO, sulfinate, and 2-nitrostyrene, C-O bond cleavage to give the parent sulfohydroxamic acid and 2-nitrostyrene, and O-N bond cleavage to release a sulfonamide and 2-nitrophenylacetaldehyde. Laser flash photolysis experiments provide support for a Norrish type II mechanism involving 1,5-hydrogen atom abstraction to generate an aci-nitro species. A mechanism is proposed in which the (Z)-aci-nitro intermediate undergoes either C-O bond cleavage to release RSO2NHO(H), concerted C-O/N-S bond cleavage to generate sulfinate and HNO, or isomerization to the (E)-isomer prior to O-N bond cleavage. The pKa of the N(H) of the N-hydroxysulfonamide plays a key role in determining whether C-O or concerted C-O/N-S bond cleavage occurs. Deprotonating this site favors the desired C-O/N-S bond cleavage at the expense of an increased level of undesired O-N bond cleavage. Triplet state quenchers have no effect on the observed photoproducts.

4H-PYRROLO[3,2-C]PYRIDIN-4-ONE DERIVATIVES

Compounds of formula (I) for use in the treatment or prophylaxis of a disease, which is a hyperproliferative disease and/or a disorder responsive to induction of cell death, selected from a haematological tumour, a solid tumour and/or metastases thereof, said tumour harbouring a mutant EGFR with exon 19 or 21 mutations, and their use as pharmaceuticals.

4H-PYRROLO[3,2-C]PYRIDIN-4-ONE DERIVATIVES

Compounds of formula (I) processes for their production and their use as pharmaceuticals.

Synthetic process of aromatic acetaldehyde compound

The invention provides a synthetic process of an aromatic acetaldehyde compound; the synthetic method includes forming a mixed solution via starting material A with N,N-dimethylformamide dimethyl acetal; continuously feeding the mixed solution into a continuous reactor to carry out enamination reaction to obtain enamide B, and discharging the enamide B from the continuous reactor during enamination reaction; preparing aromatic acetaldehyde compound C with the enamide B, wherein the starting material A has a structural formula shown as formula (1), the enamide B has a structural formula shown as formula (2), and the aromatic acetaldehyde compound C has a structural formula shown as formula (3). By continuously feeding the mixed solution of reaction materials into the reactor to carry out enamination reaction, enamination reaction is continuously performed; continuous production of aromatic acetaldehyde compounds is achieved, reaction time is shortened, and reaction efficiency is improved.

Synthesis of indolines via a SmI2 promoted domino nitro reduction-intramolecular aza-Michael reaction

A simple and straightforward synthesis of substituted indolines based on a domino nitro reduction intramolecular aza-Michael reaction is described. The reaction employs Samarium diiodide under mild conditions for the addition of dibromoacetic acid to substituted 2-(2-nitrophenyl) acetaldehyde derivatives and their subsequent cyclization upon nitro group reduction to provide corresponding indoline heterocycles in good yields. This "one pot" strategy also permitted the expeditious synthesis of a 1,2,3,4-tetrahydroquinoline, whereas the seven-membered 2,3,4,5-tetrahydrobenzoazepines compounds were not formed under these reaction conditions.

Facile synthesis of indolines by a tandem nitro-reduction Aza Michael addition reaction

A diverse array of substrates are conveniently prepared by coupling diazonium salts to ethyl vinyl ether and subjecting the resultant aldehyde intermediate to a Wittig reaction to provide α,β-unsaturated esters with only one purification step. The cyclisation of 4-aryl-but-2-enoates is carried out in the presence of stoichiometric amounts of SnCl 22H2O and thus this one-pot strategy also permitted the expeditious synthesis of indolines in good yield. The Japan Institute of Heterocyclic Chemistry.

Continuous-flow synthesis of monoarylated acetaldehydes using aryldiazonium salts

Anilines and ethyl vinyl ether can be used as precursors for a process that is the synthetic equivalent of the α-arylation of acetaldehyde enolate. The reaction manifests a high level of functional group compatibility, allowing the ready preparation of a number of synthetically valuable compounds.

WNT PATHWAY ANTAGONISTS

The present invention relates to known and novel compounds of formula (I) as herein described and pharmaceutical compositions thereof. The compounds of formula (I) have inhibitory effect on the Wnt pathway and are therefore useful in the preparation of a medicament, in particular for the treatment of cancer.