2-(2-fluoro-4-(trifluoromethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Base Information

• Chemical Name: 2-(2-fluoro-4-(trifluoromethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
• CAS No.: 1073477-73-2
• Molecular Formula: C₁₃H₁₅BF₄O₃
• Molecular Weight: 306.065
• Mol file: 1073477-73-2.mol

Synonyms:2-(2-fluoro-4-(trifluoromethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Chemical Property of 2-(2-fluoro-4-(trifluoromethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-fluoro-4-(trifluoromethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

There total 4 articles about 2-(2-fluoro-4-(trifluoromethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.4%

1-bromo-2-fluoro-4-(trifluoromethoxy)benzene (168971-68-4) + bis(pinacol)diborane (73183-34-3) → 2-(2-fluoro-4-(trifluoromethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1073477-73-2)

Guidance literature:

With potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In dimethyl sulfoxide; at 80 ℃; for 15h;

Reference yield:

2-fluoro-1-nitro-4-(trifluoromethoxy) benzene (123572-64-5) → 2-(2-fluoro-4-(trifluoromethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1073477-73-2)

Guidance literature:

Multi-step reaction with 3 steps

1: palladium on activated charcoal; hydrogen / methanol / 20 - 30 °C

2: tert.-butylnitrite; copper(I) bromide / acetonitrile / 0.5 h / 60 °C / Inert atmosphere

3: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 100 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tert.-butylnitrite; palladium on activated charcoal; hydrogen; potassium acetate; copper(I) bromide; In 1,4-dioxane; methanol; acetonitrile;

Reference yield:

meta-fluoro(trifluoromethoxy)benzene (1077-01-6) → 2-(2-fluoro-4-(trifluoromethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1073477-73-2)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium nitrate; sulfuric acid / 30 °C / Cooling with ice; Inert atmosphere

2: palladium on activated charcoal; hydrogen / methanol / 20 - 30 °C

3: tert.-butylnitrite; copper(I) bromide / acetonitrile / 0.5 h / 60 °C / Inert atmosphere

4: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 100 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tert.-butylnitrite; sulfuric acid; palladium on activated charcoal; hydrogen; potassium acetate; potassium nitrate; copper(I) bromide; In 1,4-dioxane; methanol; acetonitrile;

upstream raw materials:

1-bromo-2-fluoro-4-(trifluoromethoxy)benzene

bis(pinacol)diborane

2-fluoro-1-nitro-4-(trifluoromethoxy) benzene

meta-fluoro(trifluoromethoxy)benzene

Downstream raw materials:

2-fluoro-4-(trifluoromethoxy) phenol

Methyl 2-(2-fluoro-4-(trifluoromethoxy)phenyl)isonicotinate