3-[3-[5-benzyloxy-2-ethyl-4-(4-fluorophenyl)phenoxy]propoxy]-2-propylanilinehydrochloride

Base Information

Chemical Name:3-[3-[5-benzyloxy-2-ethyl-4-(4-fluorophenyl)phenoxy]propoxy]-2-propylanilinehydrochloride
CAS No.:1447667-00-6
Molecular Formula:C₃₃H₃₆FNO₃*ClH
Molecular Weight:550.113
Hs Code.:

Synonyms:3-[3-[5-benzyloxy-2-ethyl-4-(4-fluorophenyl)phenoxy]propoxy]-2-propylanilinehydrochloride

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Chemical Property of 3-[3-[5-benzyloxy-2-ethyl-4-(4-fluorophenyl)phenoxy]propoxy]-2-propylanilinehydrochloride

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Technology Process of 3-[3-[5-benzyloxy-2-ethyl-4-(4-fluorophenyl)phenoxy]propoxy]-2-propylanilinehydrochloride

There total 10 articles about 3-[3-[5-benzyloxy-2-ethyl-4-(4-fluorophenyl)phenoxy]propoxy]-2-propylanilinehydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1447666-99-0
methyl N-[3-[3-[5-benzyloxy-2-ethyl-4-(4-fluorophenyl)phenoxy]propoxy]-2-propylphenyl]carbamate

: 1447667-00-6
3-[3-[5-benzyloxy-2-ethyl-4-(4-fluorophenyl)phenoxy]propoxy]-2-propylanilinehydrochloride

Guidance literature:: methyl N-[3-[3-[5-benzyloxy-2-ethyl-4-(4-fluorophenyl)phenoxy]propoxy]-2-propylphenyl]carbamate; With potassium hydroxide; In 1-methyl-pyrrolidin-2-one; at 110 - 120 ℃; for 2h;

With hydrogenchloride; In tert-butyl methyl ether; ethyl acetate;

Reference yield:

: 1409654-45-0
tert-butyl 2,3-dimethoxybenzoate

: 1447667-00-6
3-[3-[5-benzyloxy-2-ethyl-4-(4-fluorophenyl)phenoxy]propoxy]-2-propylanilinehydrochloride

Guidance literature:: Multi-step reaction with 8 steps

1.1: acetic acid / tetrahydrofuran; diethyl ether / 3.5 h / -12 - -10 °C

2.1: boron tribromide / toluene / 3 h / -25 - -5 °C

2.2: 0.5 h / 7 °C

3.1: thionyl chloride / 35.5 h / -10 °C

4.1: potassium carbonate; dmap / dimethyl sulfoxide / 87 h / 60 °C

5.1: potassium hydroxide / 1-methyl-pyrrolidin-2-one / 0.42 h / 120 °C

6.1: N,N-dimethyl-formamide; thionyl chloride / tetrahydrofuran / 1 h / 0 - 5 °C

6.2: 0.5 h / 0 - 5 °C

7.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; N-Bromosuccinimide / methanol / 22 h / -10 - -5 °C

8.1: potassium hydroxide / 1-methyl-pyrrolidin-2-one / 2 h / 110 - 120 °C

With dmap; N-Bromosuccinimide; thionyl chloride; boron tribromide; potassium carbonate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; N,N-dimethyl-formamide; potassium hydroxide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; diethyl ether; dimethyl sulfoxide; toluene;

Reference yield:

: 168899-38-5
3-hydroxy-2-propylbenzoic acid

: 1447667-00-6
3-[3-[5-benzyloxy-2-ethyl-4-(4-fluorophenyl)phenoxy]propoxy]-2-propylanilinehydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: thionyl chloride / 35.5 h / -10 °C

2.1: potassium carbonate; dmap / dimethyl sulfoxide / 87 h / 60 °C

3.1: potassium hydroxide / 1-methyl-pyrrolidin-2-one / 0.42 h / 120 °C

4.1: N,N-dimethyl-formamide; thionyl chloride / tetrahydrofuran / 1 h / 0 - 5 °C

4.2: 0.5 h / 0 - 5 °C

5.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; N-Bromosuccinimide / methanol / 22 h / -10 - -5 °C

6.1: potassium hydroxide / 1-methyl-pyrrolidin-2-one / 2 h / 110 - 120 °C

With dmap; N-Bromosuccinimide; thionyl chloride; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; N,N-dimethyl-formamide; potassium hydroxide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; dimethyl sulfoxide;