methyl N-[3-[3-[5-benzyloxy-2-ethyl-4-(4-fluorophenyl)phenoxy]propoxy]-2-propylphenyl]carbamate

Base Information

Chemical Name:methyl N-[3-[3-[5-benzyloxy-2-ethyl-4-(4-fluorophenyl)phenoxy]propoxy]-2-propylphenyl]carbamate
CAS No.:1447666-99-0
Molecular Formula:C₃₅H₃₈FNO₅
Molecular Weight:571.689
Hs Code.:

Synonyms:methyl N-[3-[3-[5-benzyloxy-2-ethyl-4-(4-fluorophenyl)phenoxy]propoxy]-2-propylphenyl]carbamate

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Chemical Property of methyl N-[3-[3-[5-benzyloxy-2-ethyl-4-(4-fluorophenyl)phenoxy]propoxy]-2-propylphenyl]carbamate

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Technology Process of methyl N-[3-[3-[5-benzyloxy-2-ethyl-4-(4-fluorophenyl)phenoxy]propoxy]-2-propylphenyl]carbamate

There total 9 articles about methyl N-[3-[3-[5-benzyloxy-2-ethyl-4-(4-fluorophenyl)phenoxy]propoxy]-2-propylphenyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 67-56-1
methanol

: 1447666-98-9
3-[3-[5-benzyloxy-2-ethyl-4-(4-fluorophenyl)phenoxy]propoxy]-2-propylbenzamide

: 1447666-99-0
methyl N-[3-[3-[5-benzyloxy-2-ethyl-4-(4-fluorophenyl)phenoxy]propoxy]-2-propylphenyl]carbamate

Guidance literature:: With N-Bromosuccinimide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In methanol; at -10 - -5 ℃; for 22h;

Reference yield:

: 1409654-45-0
tert-butyl 2,3-dimethoxybenzoate

: 1447666-99-0
methyl N-[3-[3-[5-benzyloxy-2-ethyl-4-(4-fluorophenyl)phenoxy]propoxy]-2-propylphenyl]carbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: acetic acid / tetrahydrofuran; diethyl ether / 3.5 h / -12 - -10 °C

2.1: boron tribromide / toluene / 3 h / -25 - -5 °C

2.2: 0.5 h / 7 °C

3.1: thionyl chloride / 35.5 h / -10 °C

4.1: potassium carbonate; dmap / dimethyl sulfoxide / 87 h / 60 °C

5.1: potassium hydroxide / 1-methyl-pyrrolidin-2-one / 0.42 h / 120 °C

6.1: N,N-dimethyl-formamide; thionyl chloride / tetrahydrofuran / 1 h / 0 - 5 °C

6.2: 0.5 h / 0 - 5 °C

7.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; N-Bromosuccinimide / methanol / 22 h / -10 - -5 °C

With dmap; N-Bromosuccinimide; thionyl chloride; boron tribromide; potassium carbonate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; N,N-dimethyl-formamide; potassium hydroxide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; diethyl ether; dimethyl sulfoxide; toluene;

Reference yield:

: 7169-06-4
2,3-dimethoxybenzoyl chloride

: 1447666-99-0
methyl N-[3-[3-[5-benzyloxy-2-ethyl-4-(4-fluorophenyl)phenoxy]propoxy]-2-propylphenyl]carbamate

Guidance literature:: Multi-step reaction with 8 steps

1.1: pyridine; dmap / dichloromethane / 1.08 h / Reflux

2.1: acetic acid / tetrahydrofuran; diethyl ether / 3.5 h / -12 - -10 °C

3.1: boron tribromide / toluene / 3 h / -25 - -5 °C

3.2: 0.5 h / 7 °C

4.1: thionyl chloride / 35.5 h / -10 °C

5.1: potassium carbonate; dmap / dimethyl sulfoxide / 87 h / 60 °C

6.1: potassium hydroxide / 1-methyl-pyrrolidin-2-one / 0.42 h / 120 °C

7.1: N,N-dimethyl-formamide; thionyl chloride / tetrahydrofuran / 1 h / 0 - 5 °C

7.2: 0.5 h / 0 - 5 °C

8.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; N-Bromosuccinimide / methanol / 22 h / -10 - -5 °C

With pyridine; dmap; N-Bromosuccinimide; thionyl chloride; boron tribromide; potassium carbonate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; N,N-dimethyl-formamide; potassium hydroxide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; diethyl ether; dichloromethane; dimethyl sulfoxide; toluene;