7-(4-methoxyphenyl)-5,7-dihydro-6H-10-thia-7a,11-diaza-cyclopenta[b]phenanthren-8-one

Base Information

• Chemical Name: 7-(4-methoxyphenyl)-5,7-dihydro-6H-10-thia-7a,11-diaza-cyclopenta[b]phenanthren-8-one
• CAS No.: 157282-77-4
• Molecular Formula: C₂₁H₁₈N₂O₂S
• Molecular Weight: 362.452

Synonyms:7-(4-methoxyphenyl)-5,7-dihydro-6H-10-thia-7a,11-diaza-cyclopenta[b]phenanthren-8-one

Chemical Property of 7-(4-methoxyphenyl)-5,7-dihydro-6H-10-thia-7a,11-diaza-cyclopenta[b]phenanthren-8-one

Chemical Property:

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Technology Process of 7-(4-methoxyphenyl)-5,7-dihydro-6H-10-thia-7a,11-diaza-cyclopenta[b]phenanthren-8-one

There total 7 articles about 7-(4-methoxyphenyl)-5,7-dihydro-6H-10-thia-7a,11-diaza-cyclopenta[b]phenanthren-8-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-methoxy-benzaldehyde (123-11-5) + thiourea (17356-08-0) + chloroacetyl chloride (79-04-9) + 3,4-dihydronaphthalene-1(2H)-one (529-34-0) → 7-(4-methoxyphenyl)-5,7-dihydro-6H-10-thia-7a,11-diaza-cyclopenta[b]phenanthren-8-one (157282-77-4)

Guidance literature:

4-methoxy-benzaldehyde; thiourea; 3,4-dihydronaphthalene-1(2H)-one; With N-methyl-2-oxopyrrolidin-1-ium dihydrogen phosphate; at 90 ℃; Microwave irradiation; Green chemistry;

chloroacetyl chloride; With N-methyl-2-oxopyrrolidin-1-ium dihydrogen phosphate; at 90 ℃; for 0.05h; Microwave irradiation; Green chemistry;

DOI:10.1007/s11164-015-2249-1

Reference yield: 72.0%

9-(4-chlorophenyl)-7-(4-methoxyphenyl)-6,7-dihydro-5H-benzo[h]thiazolo[2,3-b]quinazoline (134408-32-5) + N-chloroacetyl-aniline (587-65-5) → 7-(4-methoxyphenyl)-5,7-dihydro-6H-10-thia-7a,11-diaza-cyclopenta[b]phenanthren-8-one (157282-77-4)

Guidance literature:

With acetic acid; for 5h; Reagent/catalyst; Reflux;

DOI:10.1016/j.tetlet.2013.11.001

Reference yield: 70.0%

9-(4-chlorophenyl)-7-(4-methoxyphenyl)-6,7-dihydro-5H-benzo[h]thiazolo[2,3-b]quinazoline (134408-32-5) + chloroacetic acid (79-11-8) → 7-(4-methoxyphenyl)-5,7-dihydro-6H-10-thia-7a,11-diaza-cyclopenta[b]phenanthren-8-one (157282-77-4)

Guidance literature:

With sodium acetate; acetic anhydride; acetic acid; for 2h; Heating;

upstream raw materials:

9-(4-chlorophenyl)-7-(4-methoxyphenyl)-6,7-dihydro-5H-benzo[h]thiazolo[2,3-b]quinazoline

chloroacetic acid

2-(4-methoxybenzylidene)-1-tetralone

N-chloroacetyl-aniline

Downstream raw materials:

(Z)-3-(5-((7-(4-methoxyphenyl)-9-oxo-5H-benzo[h]thiazolo[2,3-b]quinazolin-10(6H,7H,9H)-ylidene)methyl)furan-2-yl)-4-methylbenzoic acid

(Z)-3-((2-methoxy-4-((7-(4-methoxyphenyl)-9-oxo-5H-benzo[h]thiazolo[2,3-b]quinazolin-10(6H,7H,9H)-ylidene)methyl)phenoxy)methyl)benzoic acid

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