2'-acetamido-4-(benzyloxy)-1',2',3',6'-tetrahydro-[1,1'-biphenyl]-2-yl trifluoromethanesulfonate

Base Information

Chemical Name:2'-acetamido-4-(benzyloxy)-1',2',3',6'-tetrahydro-[1,1'-biphenyl]-2-yl trifluoromethanesulfonate
CAS No.:1382722-67-9
Molecular Formula:C₂₂H₂₂F₃NO₅S
Molecular Weight:469.482
Hs Code.:

Synonyms:2'-acetamido-4-(benzyloxy)-1',2',3',6'-tetrahydro-[1,1'-biphenyl]-2-yl trifluoromethanesulfonate

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Chemical Property of 2'-acetamido-4-(benzyloxy)-1',2',3',6'-tetrahydro-[1,1'-biphenyl]-2-yl trifluoromethanesulfonate

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Technology Process of 2'-acetamido-4-(benzyloxy)-1',2',3',6'-tetrahydro-[1,1'-biphenyl]-2-yl trifluoromethanesulfonate

There total 10 articles about 2'-acetamido-4-(benzyloxy)-1',2',3',6'-tetrahydro-[1,1'-biphenyl]-2-yl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 37595-74-7
N,N-phenylbistrifluoromethane-sulfonimide

: 1382722-65-7
N-(4'-(benzyloxy)-2'-hydroxy-1,2,3,6-tetrahydro-[1,1'-biphenyl]-2-yl)acetamide

: 1382722-67-9
2'-acetamido-4-(benzyloxy)-1',2',3',6'-tetrahydro-[1,1'-biphenyl]-2-yl trifluoromethanesulfonate

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃;
DOI:10.1021/jm300544c

Reference yield:

: 52085-14-0
4-benzoxy-salicylaldehyde

: 1382722-67-9
2'-acetamido-4-(benzyloxy)-1',2',3',6'-tetrahydro-[1,1'-biphenyl]-2-yl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 7 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

2: ammonium acetate / 0.33 h / 50 °C

3: toluene / 48 h / -78 - 120 °C / Sealed tube

4: hydrogenchloride; zinc / isopropyl alcohol / 1.5 h / 50 °C

5: triethylamine / dichloromethane / 3 h / 20 °C

6: hydrogenchloride / methanol / 50 °C

7: triethylamine / dichloromethane / 0 °C

With hydrogenchloride; ammonium acetate; triethylamine; N-ethyl-N,N-diisopropylamine; zinc; In methanol; dichloromethane; isopropyl alcohol; toluene; 2: Henry reaction;
DOI:10.1021/jm300544c

Reference yield:

: 1382722-63-5
4'-(benzyloxy)-2'-(methoxymethoxy)-2-nitro-1,2,3,6-tetrahydro-1,1'-biphenyl

: 1382722-67-9
2'-acetamido-4-(benzyloxy)-1',2',3',6'-tetrahydro-[1,1'-biphenyl]-2-yl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride; zinc / isopropyl alcohol / 1.5 h / 50 °C

2: triethylamine / dichloromethane / 3 h / 20 °C

3: hydrogenchloride / methanol / 50 °C

4: triethylamine / dichloromethane / 0 °C

With hydrogenchloride; triethylamine; zinc; In methanol; dichloromethane; isopropyl alcohol;
DOI:10.1021/jm300544c