Technology Process of 1α,3β,25-thihydroxy-26,26,26,27,27,27-hexafluorocholest-5-ene-24-yl phenyl sulfone 1,3-bis(triethylsilyl) ether
There total 13 articles about 1α,3β,25-thihydroxy-26,26,26,27,27,27-hexafluorocholest-5-ene-24-yl phenyl sulfone 1,3-bis(triethylsilyl) ether which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
n-butyllithium; diisopropylamine;
In
tetrahydrofuran;
at -78 ℃;
for 0.05h;
DOI:10.1248/cpb.30.4297
- Guidance literature:
-
Multi-step reaction with 7 steps
2: 149 mg / pyridine / 0 °C
3: 53 percent / LiBr / dimethylformamide / 2 h / Heating
4: 92 percent / dimethylformamide / 4 h / 70 - 80 °C
5: 85 percent / 5percent KOH / methanol; tetrahydrofuran / 18 h / Ambient temperature
6: 57 percent / triethylamine / pyridine / 15 h / Ambient temperature
7: 74 percent / diisopropylamine, n-BuLi / tetrahydrofuran / 0.05 h / -78 °C
With
potassium hydroxide; n-butyllithium; triethylamine; diisopropylamine; lithium bromide;
In
tetrahydrofuran; pyridine; methanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.30.4297
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 80 percent / 5percent NaOH, 30percent H2O2 / methanol / 18 h / Heating
2: 65 percent / lithium, anhydrous NH4Cl / liquid ammonia; tetrahydrofuran / 2 h / -78 °C
4: 149 mg / pyridine / 0 °C
5: 53 percent / LiBr / dimethylformamide / 2 h / Heating
6: 92 percent / dimethylformamide / 4 h / 70 - 80 °C
7: 85 percent / 5percent KOH / methanol; tetrahydrofuran / 18 h / Ambient temperature
8: 57 percent / triethylamine / pyridine / 15 h / Ambient temperature
9: 74 percent / diisopropylamine, n-BuLi / tetrahydrofuran / 0.05 h / -78 °C
With
potassium hydroxide; sodium hydroxide; n-butyllithium; dihydrogen peroxide; lithium; ammonium chloride; triethylamine; diisopropylamine; lithium bromide;
In
tetrahydrofuran; pyridine; methanol; ammonia; N,N-dimethyl-formamide;
DOI:10.1248/cpb.30.4297
