25,26,27-trisnorcholesta-1,4,6-trien-3-on-24-oic acid methyl ester

Base Information

Chemical Name:25,26,27-trisnorcholesta-1,4,6-trien-3-on-24-oic acid methyl ester
CAS No.:80097-58-1
Molecular Formula:C₂₅H₃₄O₃
Molecular Weight:382.543
Hs Code.:

Synonyms:25,26,27-trisnorcholesta-1,4,6-trien-3-on-24-oic acid methyl ester

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Chemical Property of 25,26,27-trisnorcholesta-1,4,6-trien-3-on-24-oic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

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Technology Process of 25,26,27-trisnorcholesta-1,4,6-trien-3-on-24-oic acid methyl ester

There total 1 articles about 25,26,27-trisnorcholesta-1,4,6-trien-3-on-24-oic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 14773-00-3
methyl (5β,7α)-12-hydroxy-3-oxo-cholan-24-oate

: 80097-58-1
25,26,27-trisnorcholesta-1,4,6-trien-3-on-24-oic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 76 percent / POCl₃, pyridine / 16 h / Ambient temperature

2: 98 percent / tri-N-methylanilinium perbromide / tetrahydrofuran / 1.) 0 deg C, 15 min, 2.) r.t., 30 min

3: Li₂CO₃, LiBr / dimethylformamide / 0.5 h / Heating

With pyridine; phenyltrimethylammonium tribromide; lithium carbonate; lithium bromide; trichlorophosphate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)86327-4

Reference yield:

: 80097-58-1
25,26,27-trisnorcholesta-1,4,6-trien-3-on-24-oic acid methyl ester

: 26,26,26,27,27,27-hexafluoro-1α,25-dihydroxycholecalciferol triacetate

Guidance literature:: Multi-step reaction with 14 steps

1: 80 percent / 5percent NaOH, 30percent H₂O₂ / methanol / 18 h / Heating

2: 65 percent / lithium, anhydrous NH₄Cl / liquid ammonia; tetrahydrofuran / 2 h / -78 °C

4: 149 mg / pyridine / 0 °C

5: 53 percent / LiBr / dimethylformamide / 2 h / Heating

6: 92 percent / dimethylformamide / 4 h / 70 - 80 °C

7: 85 percent / 5percent KOH / methanol; tetrahydrofuran / 18 h / Ambient temperature

8: 57 percent / triethylamine / pyridine / 15 h / Ambient temperature

9: 74 percent / diisopropylamine, n-BuLi / tetrahydrofuran / 0.05 h / -78 °C

10: 99 percent / 1N HCl / 1,2-dimethoxy-ethane; methanol / 1 h / Ambient temperature

11: 72 percent / Na₂HPO₄, 5percent Na(Hg) / methanol / 2.25 h / Ambient temperature

12: 98 percent / 4-dimethylaminopyridine / pyridine / 20 h / Ambient temperature

14: 1.) benzene, ethanol, ice-cooling, irradiation, 2.5 min; 2.) benzene, ethanol, reflux, 1 h

With hydrogenchloride; potassium hydroxide; sodium hydroxide; disodium hydrogenphosphate; n-butyllithium; sodium amalgam; dihydrogen peroxide; lithium; ammonium chloride; triethylamine; diisopropylamine; lithium bromide; dmap; In tetrahydrofuran; pyridine; methanol; 1,2-dimethoxyethane; ammonia; N,N-dimethyl-formamide;
DOI:10.1248/cpb.30.4297

Reference yield:

: 80097-58-1
25,26,27-trisnorcholesta-1,4,6-trien-3-on-24-oic acid methyl ester

: 85382-50-9
1α,3β,25-thihydroxy-26,26,26,27,27,27-hexafluorocholest-5-ene-24-yl phenyl sulfone 1,3-bis(triethylsilyl) ether

Guidance literature:: Multi-step reaction with 9 steps

1: 80 percent / 5percent NaOH, 30percent H₂O₂ / methanol / 18 h / Heating

2: 65 percent / lithium, anhydrous NH₄Cl / liquid ammonia; tetrahydrofuran / 2 h / -78 °C

4: 149 mg / pyridine / 0 °C

5: 53 percent / LiBr / dimethylformamide / 2 h / Heating

6: 92 percent / dimethylformamide / 4 h / 70 - 80 °C

7: 85 percent / 5percent KOH / methanol; tetrahydrofuran / 18 h / Ambient temperature

8: 57 percent / triethylamine / pyridine / 15 h / Ambient temperature

9: 74 percent / diisopropylamine, n-BuLi / tetrahydrofuran / 0.05 h / -78 °C

With potassium hydroxide; sodium hydroxide; n-butyllithium; dihydrogen peroxide; lithium; ammonium chloride; triethylamine; diisopropylamine; lithium bromide; In tetrahydrofuran; pyridine; methanol; ammonia; N,N-dimethyl-formamide;
DOI:10.1248/cpb.30.4297