25,26,27-trisnor-1α,3β-bistriethylsiloxycholest-5-ene-24-yl phenyl sulfone

Base Information

Chemical Name:25,26,27-trisnor-1α,3β-bistriethylsiloxycholest-5-ene-24-yl phenyl sulfone
CAS No.:85382-49-6
Molecular Formula:C₄₂H₇₂O₄SSi₂
Molecular Weight:729.268
Hs Code.:

Synonyms:25,26,27-trisnor-1α,3β-bistriethylsiloxycholest-5-ene-24-yl phenyl sulfone

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Chemical Property of 25,26,27-trisnor-1α,3β-bistriethylsiloxycholest-5-ene-24-yl phenyl sulfone

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Technology Process of 25,26,27-trisnor-1α,3β-bistriethylsiloxycholest-5-ene-24-yl phenyl sulfone

There total 11 articles about 25,26,27-trisnor-1α,3β-bistriethylsiloxycholest-5-ene-24-yl phenyl sulfone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 994-30-9
triethylsilyl chloride

: 85382-53-2
(1S,3R,8S,9S,10R,13R,14S,17R)-17-((R)-4-Benzenesulfonyl-1-methyl-butyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-1,3-diol

: 85382-49-6
25,26,27-trisnor-1α,3β-bistriethylsiloxycholest-5-ene-24-yl phenyl sulfone

Guidance literature:: With triethylamine; In pyridine; for 15h; Ambient temperature;
DOI:10.1248/cpb.30.4297

Reference yield:

: 85382-45-2
25,26,27-trisnorcholest-5-ene-1α,3β,24-triol

: 85382-49-6
25,26,27-trisnor-1α,3β-bistriethylsiloxycholest-5-ene-24-yl phenyl sulfone

Guidance literature:: Multi-step reaction with 6 steps

2: 149 mg / pyridine / 0 °C

3: 53 percent / LiBr / dimethylformamide / 2 h / Heating

4: 92 percent / dimethylformamide / 4 h / 70 - 80 °C

5: 85 percent / 5percent KOH / methanol; tetrahydrofuran / 18 h / Ambient temperature

6: 57 percent / triethylamine / pyridine / 15 h / Ambient temperature

With potassium hydroxide; triethylamine; lithium bromide; In tetrahydrofuran; pyridine; methanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.30.4297

Reference yield:

: 80097-58-1
25,26,27-trisnorcholesta-1,4,6-trien-3-on-24-oic acid methyl ester

: 85382-49-6
25,26,27-trisnor-1α,3β-bistriethylsiloxycholest-5-ene-24-yl phenyl sulfone

Guidance literature:: Multi-step reaction with 8 steps

1: 80 percent / 5percent NaOH, 30percent H₂O₂ / methanol / 18 h / Heating

2: 65 percent / lithium, anhydrous NH₄Cl / liquid ammonia; tetrahydrofuran / 2 h / -78 °C

4: 149 mg / pyridine / 0 °C

5: 53 percent / LiBr / dimethylformamide / 2 h / Heating

6: 92 percent / dimethylformamide / 4 h / 70 - 80 °C

7: 85 percent / 5percent KOH / methanol; tetrahydrofuran / 18 h / Ambient temperature

8: 57 percent / triethylamine / pyridine / 15 h / Ambient temperature

With potassium hydroxide; sodium hydroxide; dihydrogen peroxide; lithium; ammonium chloride; triethylamine; lithium bromide; In tetrahydrofuran; pyridine; methanol; ammonia; N,N-dimethyl-formamide;
DOI:10.1248/cpb.30.4297