N-(cyclopropylmethyl)-3-[[3-methoxy-5-(trifluoromethyl)phenyl]amino]-1-(2-methyl-4-pyridinyl)-1H-pyrazole-5-acetamide

Base Information

Chemical Name:N-(cyclopropylmethyl)-3-[[3-methoxy-5-(trifluoromethyl)phenyl]amino]-1-(2-methyl-4-pyridinyl)-1H-pyrazole-5-acetamide
CAS No.:1274885-12-9
Molecular Formula:C₂₃H₂₄F₃N₅O₂
Molecular Weight:459.471
Hs Code.:

Synonyms:N-(cyclopropylmethyl)-3-[[3-methoxy-5-(trifluoromethyl)phenyl]amino]-1-(2-methyl-4-pyridinyl)-1H-pyrazole-5-acetamide

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Chemical Property of N-(cyclopropylmethyl)-3-[[3-methoxy-5-(trifluoromethyl)phenyl]amino]-1-(2-methyl-4-pyridinyl)-1H-pyrazole-5-acetamide

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Technology Process of N-(cyclopropylmethyl)-3-[[3-methoxy-5-(trifluoromethyl)phenyl]amino]-1-(2-methyl-4-pyridinyl)-1H-pyrazole-5-acetamide

There total 9 articles about N-(cyclopropylmethyl)-3-[[3-methoxy-5-(trifluoromethyl)phenyl]amino]-1-(2-methyl-4-pyridinyl)-1H-pyrazole-5-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1274885-10-7
3-[[3-methoxy-5-(trifluoromethyl)phenyl]amino]-1-(2-methyl-4-pyridinyl)-1H-pyrazole-5-acetic acid methyl ester

: 2516-47-4
cyclopropanemethylamine

: 1274885-12-9
N-(cyclopropylmethyl)-3-[[3-methoxy-5-(trifluoromethyl)phenyl]amino]-1-(2-methyl-4-pyridinyl)-1H-pyrazole-5-acetamide

Guidance literature:: at 20 ℃; for 6h;

Reference yield:

: 349-55-3
5-(trifluoromethyl)-m-anisidine

: 1274885-12-9
N-(cyclopropylmethyl)-3-[[3-methoxy-5-(trifluoromethyl)phenyl]amino]-1-(2-methyl-4-pyridinyl)-1H-pyrazole-5-acetamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: copper(I) bromide; sodium nitrite; sulfuric acid; hydrogen bromide / acetic acid / 0 - 20 °C

2.1: sodium t-butanolate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / tetrahydrofuran / 2 h / 110 °C / Microwave irradiation

3.1: manganese(IV) oxide / dichloromethane / 6 h / 20 °C

4.1: boron tribromide / dichloromethane / 1 h / -10 °C / Inert atmosphere

5.1: triethylamine; methanesulfonyl chloride / tetrahydrofuran / 3 h / 20 °C

5.2: 1 h / Reflux; Inert atmosphere

6.1: hydrogenchloride / water / 3 h / 70 °C

6.3: Cooling

7.1: 6 h / 20 °C

With hydrogenchloride; manganese(IV) oxide; sulfuric acid; hydrogen bromide; boron tribromide; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; methanesulfonyl chloride; triethylamine; copper(I) bromide; sodium t-butanolate; sodium nitrite; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; water; acetic acid;

Reference yield:

: 627527-23-5
1-bromo-3-methoxy-5-(trifluoromethyl)benzene

: 1274885-12-9
N-(cyclopropylmethyl)-3-[[3-methoxy-5-(trifluoromethyl)phenyl]amino]-1-(2-methyl-4-pyridinyl)-1H-pyrazole-5-acetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium t-butanolate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / tetrahydrofuran / 2 h / 110 °C / Microwave irradiation

2.1: manganese(IV) oxide / dichloromethane / 6 h / 20 °C

3.1: boron tribromide / dichloromethane / 1 h / -10 °C / Inert atmosphere

4.1: triethylamine; methanesulfonyl chloride / tetrahydrofuran / 3 h / 20 °C

4.2: 1 h / Reflux; Inert atmosphere

5.1: hydrogenchloride / water / 3 h / 70 °C

5.3: Cooling

6.1: 6 h / 20 °C

With hydrogenchloride; manganese(IV) oxide; boron tribromide; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; methanesulfonyl chloride; triethylamine; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; water;