627527-23-5

Basic information

• Product Name: 3-BroMo-5-(trifluoroMethyl)anisole
• Synonyms: 3-BroMo-5-(trifluoroMethyl)anisole;1-Bromo-3-methoxy-5-trifluoromethylbenzene;3-Bromo-5-methoxybenzotrifluoride
• CAS NO: 627527-23-5
• Molecular Formula: C₈H₆BrF₃O
• Molecular Weight: 255.0318496
• Mol File: 627527-23-5.mol

Chemical Properties

• Boiling Point: 201℃
• Flash Point: 93℃
• Appearance: /
• Density: 1.563
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 3-BroMo-5-(trifluoroMethyl)anisole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BroMo-5-(trifluoroMethyl)anisole(627527-23-5)
• EPA Substance Registry System: 3-BroMo-5-(trifluoroMethyl)anisole(627527-23-5)

Safety Data

• Hazardous Substances Data: 627527-23-5(Hazardous Substances Data)

Usage

Chemical Properties

light yellow liquid

Upstream product

• 1025718-84-6 3-bromo-5-(trifluoromethyl)phenol 
• 74-88-4 methyl iodide 
• 349-55-3 5-(trifluoromethyl)-m-anisidine 
• 479411-93-3 2-(3-methoxy-5-(trifluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 

Downstream Products

• 1274885-07-2 N-[3-methoxy-5-(trifluoromethyl)phenyl]-1-(2-methyl-4-pyridinyl)-5-[(phenylmethoxy)methyl]-1H-pyrazol-3-amine 
• 1274885-08-3 3-[[3-methoxy-5-(trifluoromethyl)phenyl]amino]-1-(2-methyl-4-pyridinyl)-1H-pyrazole-5-methanol 
• 1274885-09-4 3-[[3-methoxy-5-(trifluoromethyl)phenyl]amino]-1-(2-methyl-4-pyridinyl)-1H-pyrazole-5-acetonitrile 
• 1274885-10-7 3-[[3-methoxy-5-(trifluoromethyl)phenyl]amino]-1-(2-methyl-4-pyridinyl)-1H-pyrazole-5-acetic acid methyl ester 
• 1274885-12-9 N-(cyclopropylmethyl)-3-[[3-methoxy-5-(trifluoromethyl)phenyl]amino]-1-(2-methyl-4-pyridinyl)-1H-pyrazole-5-acetamide 
• 1274885-17-4 3-[[3-methoxy-5-(trifluoromethyl)phenyl]amino]-1-(2-methyl-4-pyridinyl)-1H-pyrazole-5-propanol 
• 1274885-18-5 3-[[3-methoxy-5-(trifluoromethyl)phenyl]amino]-1-(2-methyl-4-pyridinyl)-1H-pyrazole-5-propanoic acid 
• 1274885-19-6 3-[[3-methoxy-5-(trifluoromethyl)phenyl]amino]-N,N-dimethyl-1-(2-methyl-4-pyridinyl)-1H-pyrazole-5-propanamide 
• 1274887-23-8 C₂₅H₂₅F₃N₄O₂ 
• 454-90-0 3-(trifluoromethyl)anisole 
• 1214385-12-2 1-methoxy-3-methyl-5-(trifluoromethyl)benzene 

Relevant articles and documents

NOVEL TETRAHYDROPYRIDOPYRIMIDINES AND TETRAHYDROPYRIDOPYRIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION

The invention provides novel compounds having the general formula (I): wherein R1, R2, R3, Q, U,W, Z, X and Y are as described herein, compositions including the compounds and methods of using the compounds. These compounds are HbsAg inhibitors and are useful as medicaments for the treatment or prophylaxis of HBV infection.

Substituted N-Phenyl-1-(4-Pyridinyl)-1H-Pyrazol-3-Amines

The present invention relates to N-phenyl-1-(4-pyridinyl)-1H-pyrazol-3-amine derivatives and pharmaceutically acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, according to formula (I) Wherein R1, R2, R3, R4, R5, R6 have the meaning defined in the claims. The invention particularly relates to positive allosteric modulators of nicotinic acetylcholine receptors, such positive allosteric modulator having the capability to increase the efficacy of nicotinic receptor agonists.

SUBSTITUTED N-PHENYL-1-(4-PYRIDINYL)-1H-PYRAZOL-3-AMINES

The present invention relates to N-phenyl-1-(4-pyridinyl)-1H-pyrazol-3-amine derivatives and pharmaceutically acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, according to formula (I): wherein R1, R2, R3, R4, R5, R6 have the meaning defined in the claims. The invention particularly relates to positive allosteric modulators of nicotinic acetylcholine receptors, such positive allosteric modulator having the capability to increase the efficacy of nicotinic receptor agonists.

Meta halogenation of 1,3-disubstituted arenes via iridium-catalyzed arene borylation

We report the meta halogenation of 1,3-disubstituted arenes to form 3,5-disubstituted aryl bromides and chlorides by using iridium-catalyzed arene borylation chemistry. Iridium-catalyzed borylation of arenes with B2pin2, followed by reaction of the boronic ester with copper(II) bromide or chloride converts arylboronic esters to the corresponding aryl halides. A variety of arenes containing alkoxy, alkyl, halogen, nitrile, ester, amide, and pivaloyl and TIPS-protected alcohols were converted to the corresponding 3,5-disubstituted aryl bromides and chlorides in yields ranging from 46% to 85%. In addition, 2,6-disubstituted and 3-substituted pyridines were converted to the 4-halo and 5-halopyridines, respectively. The utility of this methodology was demonstrated by the formal conversion of nicotine to Altinicline in three steps with an overall yield of 61% using meta bromination of nicotine as the first step. Copyright

Substituted imidazol-pyridazine derivatives

The present invention relates to compounds of formula wherein A is an unsubstituted or substituted cyclic group; and R is hydrogen or lower alkyl; or a pharmaceutically acceptable acid addition salt thereof. These compounds are NMDA NR-2B receptor subtype specific blockers and are useful in the treatment of neurodegeneration, depression and pain.