(3-{1-[1-(2-methoxy-ethyl)-7-methyl-1H-indole-3-carbonyl]-piperidin-4-yI}-4-methylcarbamoyl methoxy-benzyl )-carbamic acid tert-butyl ester

Base Information

Chemical Name:(3-{1-[1-(2-methoxy-ethyl)-7-methyl-1H-indole-3-carbonyl]-piperidin-4-yI}-4-methylcarbamoyl methoxy-benzyl )-carbamic acid tert-butyl ester
CAS No.:1313042-37-3
Molecular Formula:C₃₃H₄₄N₄O₆
Molecular Weight:592.736
Hs Code.:

Synonyms:(3-{1-[1-(2-methoxy-ethyl)-7-methyl-1H-indole-3-carbonyl]-piperidin-4-yI}-4-methylcarbamoyl methoxy-benzyl )-carbamic acid tert-butyl ester

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Chemical Property of (3-{1-[1-(2-methoxy-ethyl)-7-methyl-1H-indole-3-carbonyl]-piperidin-4-yI}-4-methylcarbamoyl methoxy-benzyl )-carbamic acid tert-butyl ester

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Technology Process of (3-{1-[1-(2-methoxy-ethyl)-7-methyl-1H-indole-3-carbonyl]-piperidin-4-yI}-4-methylcarbamoyl methoxy-benzyl )-carbamic acid tert-butyl ester

There total 8 articles about (3-{1-[1-(2-methoxy-ethyl)-7-methyl-1H-indole-3-carbonyl]-piperidin-4-yI}-4-methylcarbamoyl methoxy-benzyl )-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: (4-(tert-butoxycarbonyl amino-methyl)-2-{1-[1-(2-methoxy-ethyl )-7-methyl-1H-indole-3-carbonyl]-piperidin-4-yl}-phenoxy)-acetic acid

: 74-89-5
methylamine

: 1313042-37-3
(3-{1-[1-(2-methoxy-ethyl)-7-methyl-1H-indole-3-carbonyl]-piperidin-4-yI}-4-methylcarbamoyl methoxy-benzyl )-carbamic acid tert-butyl ester

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 6h;

Reference yield:

: 696-60-6
4-aminomethylphenol

: 1313042-37-3
(3-{1-[1-(2-methoxy-ethyl)-7-methyl-1H-indole-3-carbonyl]-piperidin-4-yI}-4-methylcarbamoyl methoxy-benzyl )-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: bromine; hydrogen bromide / acetic acid / 20 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

3: caesium carbonate / tetrahydrofuran / 20 °C

4: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 4 h / 80 °C

5: hydrogen; acetic acid / platinum(IV) oxide / methanol / 3 h / 20 °C / 2585.81 - 3102.97 Torr

6: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

7: sodium hydroxide; methanol / 0.5 h / 20 °C

8: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 6 h / 20 °C

With methanol; hydrogen bromide; hydrogen; bromine; caesium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; platinum(IV) oxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; acetic acid;

Reference yield:

: 63491-89-4
4-(aminomethyl)-2-bromophenol hydrogenbromide salt

: 1313042-37-3
(3-{1-[1-(2-methoxy-ethyl)-7-methyl-1H-indole-3-carbonyl]-piperidin-4-yI}-4-methylcarbamoyl methoxy-benzyl )-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

2: caesium carbonate / tetrahydrofuran / 20 °C

3: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 4 h / 80 °C

4: hydrogen; acetic acid / platinum(IV) oxide / methanol / 3 h / 20 °C / 2585.81 - 3102.97 Torr

5: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

6: sodium hydroxide; methanol / 0.5 h / 20 °C

7: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 6 h / 20 °C

With methanol; hydrogen; caesium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; platinum(IV) oxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water;