6-(1H-benzo[d]imidazol-2-yl)-2-(3-chloro-2-oxo-4-phenylazetidin-1-yl)-4-phenylnicotinonitrile

Base Information

Chemical Name:6-(1H-benzo[d]imidazol-2-yl)-2-(3-chloro-2-oxo-4-phenylazetidin-1-yl)-4-phenylnicotinonitrile
CAS No.:1456802-00-8
Molecular Formula:C₂₈H₁₈ClN₅O
Molecular Weight:475.937
Hs Code.:

Synonyms:6-(1H-benzo[d]imidazol-2-yl)-2-(3-chloro-2-oxo-4-phenylazetidin-1-yl)-4-phenylnicotinonitrile

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Chemical Property of 6-(1H-benzo[d]imidazol-2-yl)-2-(3-chloro-2-oxo-4-phenylazetidin-1-yl)-4-phenylnicotinonitrile

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Technology Process of 6-(1H-benzo[d]imidazol-2-yl)-2-(3-chloro-2-oxo-4-phenylazetidin-1-yl)-4-phenylnicotinonitrile

There total 5 articles about 6-(1H-benzo[d]imidazol-2-yl)-2-(3-chloro-2-oxo-4-phenylazetidin-1-yl)-4-phenylnicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1456802-26-8
6-(1H-benzo[d]imidazol-2-yl)-2-(benzylideneamino)-4-phenylnicotinonitrile

: 79-04-9
chloroacetyl chloride

: 1456802-00-8
6-(1H-benzo[d]imidazol-2-yl)-2-(3-chloro-2-oxo-4-phenylazetidin-1-yl)-4-phenylnicotinonitrile

Guidance literature:: With triethylamine; In 1,4-dioxane; at 0 ℃; for 9h; Reflux;
DOI:10.1007/s00044-013-0775-1

Reference yield:

: 20224-10-6
1-(1H-benzo[d]imidazol-2-yl)-3-phenylprop-2-en-1-one

: 1456802-00-8
6-(1H-benzo[d]imidazol-2-yl)-2-(3-chloro-2-oxo-4-phenylazetidin-1-yl)-4-phenylnicotinonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: ammonium acetate / ethanol / 10 h / Reflux

2: zinc(II) chloride / 1,4-dioxane / 6 h / Reflux

3: triethylamine / 1,4-dioxane / 9 h / 0 °C / Reflux

With ammonium acetate; triethylamine; zinc(II) chloride; In 1,4-dioxane; ethanol;
DOI:10.1007/s00044-013-0775-1

Reference yield:

: 100-52-7
benzaldehyde

: 1456802-00-8
6-(1H-benzo[d]imidazol-2-yl)-2-(3-chloro-2-oxo-4-phenylazetidin-1-yl)-4-phenylnicotinonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: potassium hydroxide / ethanol / 10 h

2: ammonium acetate / ethanol / 10 h / Reflux

3: zinc(II) chloride / 1,4-dioxane / 6 h / Reflux

4: triethylamine / 1,4-dioxane / 9 h / 0 °C / Reflux

With ammonium acetate; triethylamine; potassium hydroxide; zinc(II) chloride; In 1,4-dioxane; ethanol;
DOI:10.1007/s00044-013-0775-1