(R)-1-[N-(tert-butyloxycarbonyl)piperidin-2-yl]-1-phenylethene

Base Information

• Chemical Name: (R)-1-[N-(tert-butyloxycarbonyl)piperidin-2-yl]-1-phenylethene
• CAS No.: 203056-17-1
• Molecular Formula: C₁₈H₂₅NO₂
• Molecular Weight: 287.402
• Mol file: 203056-17-1.mol

Synonyms:(R)-1-[N-(tert-butyloxycarbonyl)piperidin-2-yl]-1-phenylethene

Chemical Property of (R)-1-[N-(tert-butyloxycarbonyl)piperidin-2-yl]-1-phenylethene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (R)-1-[N-(tert-butyloxycarbonyl)piperidin-2-yl]-1-phenylethene

There total 1 articles about (R)-1-[N-(tert-butyloxycarbonyl)piperidin-2-yl]-1-phenylethene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

Methyltriphenylphosphonium bromide (1779-49-3) + (R)-N-(tert-butyloxycarbonyl)piperidin-2-yl-phenylmethanone (203056-16-0) → (R)-1-[N-(tert-butyloxycarbonyl)piperidin-2-yl]-1-phenylethene (203056-17-1)

Guidance literature:

Methyltriphenylphosphonium bromide; With potassium tert-butylate; In tetrahydrofuran; for 0.333333h;

(R)-N-(tert-butyloxycarbonyl)piperidin-2-yl-phenylmethanone; In tetrahydrofuran; for 0.166667h;

DOI:10.1080/00397911.2017.1293109

Reference yield: 66.0%

(R)-1-[N-(tert-butyloxycarbonyl)piperidin-2-yl]-1-phenylethene (203056-17-1) → (1R)-1-[(2R)-N-(tert-butyloxycarbonyl)piperidin-2-yl]-1-phenyl-2-hydroxyethane (203056-18-2) + (R)-N-[tert-butoxycarbonyl]-2-[(S)-2-hydroxy-1-phenylethyl]piperidine (203056-35-3)

Guidance literature:

(R)-1-[N-(tert-butyloxycarbonyl)piperidin-2-yl]-1-phenylethene; With dimethylsulfide borane complex; In tetrahydrofuran; for 5h;

With dihydrogen peroxide; sodium hydroxide; In water;

DOI:10.1080/00397911.2017.1293109

Reference yield:

(R)-1-[N-(tert-butyloxycarbonyl)piperidin-2-yl]-1-phenylethene (203056-17-1) → (R,S)-2-[N-(tert-butyloxycarbonyl)piperidin-2-yl]-2-phenylacetic acid

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) BH₃*THF, 2.) aq. H₂O₂, NaOH / 1.) THF, RT, 4 h, 2.) THF, RT

2: PDC / dimethylformamide / 17 h

With sodium hydroxide; dipyridinium dichromate; borane-THF; dihydrogen peroxide; In N,N-dimethyl-formamide;

DOI:10.1021/jm970620j

upstream raw materials:

Methyltriphenylphosphonium bromide

(R)-N-(tert-butyloxycarbonyl)piperidin-2-yl-phenylmethanone

Downstream raw materials:

(1R)-1-[(2R)-N-(tert-butyloxycarbonyl)piperidin-2-yl]-1-phenyl-2-hydroxyethane

(R)-N-[tert-butoxycarbonyl]-2-[(S)-2-hydroxy-1-phenylethyl]piperidine

(R)-2-((R)-Methoxycarbonyl-phenyl-methyl)-piperidine-1-carboxylic acid tert-butyl ester