(1R)-1-[(2R)-N-(tert-butyloxycarbonyl)piperidin-2-yl]-1-phenyl-2-hydroxyethane

Base Information

Chemical Name:(1R)-1-[(2R)-N-(tert-butyloxycarbonyl)piperidin-2-yl]-1-phenyl-2-hydroxyethane
CAS No.:203056-18-2
Molecular Formula:C₁₈H₂₇NO₃
Molecular Weight:305.417
Hs Code.:

Synonyms:(1R)-1-[(2R)-N-(tert-butyloxycarbonyl)piperidin-2-yl]-1-phenyl-2-hydroxyethane

Suppliers and Price of (1R)-1-[(2R)-N-(tert-butyloxycarbonyl)piperidin-2-yl]-1-phenyl-2-hydroxyethane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R)-1-[(2R)-N-(tert-butyloxycarbonyl)piperidin-2-yl]-1-phenyl-2-hydroxyethane

Chemical Property:

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Technology Process of (1R)-1-[(2R)-N-(tert-butyloxycarbonyl)piperidin-2-yl]-1-phenyl-2-hydroxyethane

There total 21 articles about (1R)-1-[(2R)-N-(tert-butyloxycarbonyl)piperidin-2-yl]-1-phenyl-2-hydroxyethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 950206-50-5
C₃₄H₄₅NO₃Si

: 203056-18-2
(1R)-1-[(2R)-N-(tert-butyloxycarbonyl)piperidin-2-yl]-1-phenyl-2-hydroxyethane

Guidance literature:: With pyridine hydrogenfluoride; In tetrahydrofuran; at 20 ℃;
DOI:10.1055/s-2007-982577

Reference yield: 66.0%

: 203056-17-1
(R)-1-[N-(tert-butyloxycarbonyl)piperidin-2-yl]-1-phenylethene

: 203056-18-2
(1R)-1-[(2R)-N-(tert-butyloxycarbonyl)piperidin-2-yl]-1-phenyl-2-hydroxyethane

: 203056-35-3
(R)-N-[tert-butoxycarbonyl]-2-[(S)-2-hydroxy-1-phenylethyl]piperidine

Guidance literature:: (R)-1-[N-(tert-butyloxycarbonyl)piperidin-2-yl]-1-phenylethene; With dimethylsulfide borane complex; In tetrahydrofuran; for 5h;

With dihydrogen peroxide; sodium hydroxide; In water;
DOI:10.1080/00397911.2017.1293109

Reference yield:

: 103-82-2
phenylacetic acid

: 203056-18-2
(1R)-1-[(2R)-N-(tert-butyloxycarbonyl)piperidin-2-yl]-1-phenyl-2-hydroxyethane

Guidance literature:: Multi-step reaction with 7 steps

1: 78 percent / pivaloyl chloride, triethylamine / toluene

3: 93 percent / triethylamine / toluene / 2 h / 0 °C

4: 91 percent / NaBH₄ / tetrahydrofuran; H₂O / 0 - 22 °C

5: 60 percent / 3 h / 85 °C

6: hydrogen / Pd/C / ethanol / 4 h / 2585.74 Torr / Ambient temperature

7: 160 mg / triethylamine / tetrahydrofuran / 19 h / 22 °C

With sodium tetrahydroborate; hydrogen; pivaloyl chloride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; water; toluene;
DOI:10.1021/jo9821473