2-[5-benzyloxycarbonylamino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-[2-phenyl-1-[(2-thiazolyl)hydroxymethyl]ethyl]acetamide

Base Information

Chemical Name:2-[5-benzyloxycarbonylamino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-[2-phenyl-1-[(2-thiazolyl)hydroxymethyl]ethyl]acetamide
CAS No.:207235-89-0
Molecular Formula:C₃₂H₂₈FN₅O₅S
Molecular Weight:613.669
Hs Code.:

Synonyms:2-[5-benzyloxycarbonylamino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-[2-phenyl-1-[(2-thiazolyl)hydroxymethyl]ethyl]acetamide

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Chemical Property of 2-[5-benzyloxycarbonylamino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-[2-phenyl-1-[(2-thiazolyl)hydroxymethyl]ethyl]acetamide

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Technology Process of 2-[5-benzyloxycarbonylamino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-[2-phenyl-1-[(2-thiazolyl)hydroxymethyl]ethyl]acetamide

There total 6 articles about 2-[5-benzyloxycarbonylamino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-[2-phenyl-1-[(2-thiazolyl)hydroxymethyl]ethyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: [1-[(1-benzyl-2-thiazol-2-yl-2-trimethylsilanyloxy-ethylcarbamoyl)-methyl]-2-(4-fluoro-phenyl)-6-oxo-1,6-dihydro-pyrimidin-5-yl]-carbamic acid benzyl ester

: 207235-89-0
2-[5-benzyloxycarbonylamino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-[2-phenyl-1-[(2-thiazolyl)hydroxymethyl]ethyl]acetamide

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 0.5h;
DOI:10.1021/jm000496v

Reference yield:

: 79265-30-8
2-(trimethylsilyl)thiazole

: 429-41-4
tetrabutyl ammonium fluoride

: 144-55-8
sodium hydrogencarbonate

: 339209-10-8
2-[5-benzyloxycarbonylamino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-[1-formyl-2-phenylethyl]acetamide

: 207235-89-0
2-[5-benzyloxycarbonylamino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-[2-phenyl-1-[(2-thiazolyl)hydroxymethyl]ethyl]acetamide

Guidance literature:: In tetrahydrofuran; dichloromethane;

Reference yield:

: 1795-98-8,3182-95-4,5267-64-1,16088-07-6
rac-phenylalaninol

: 207235-89-0
2-[5-benzyloxycarbonylamino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-[2-phenyl-1-[(2-thiazolyl)hydroxymethyl]ethyl]acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 81 percent / 3-hydroxybenzotriazole hydrate; 1-[3(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride / dimethylformamide / 4 h / 20 °C

2: 93 percent / 1-[3(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride; Cl₂CHCO₂H; DMSO / toluene / 4 h / 20 °C

3: CH₂Cl₂ / 24 h / 20 °C

4: tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C

With dichloro-acetic acid; tetrabutyl ammonium fluoride; dimethyl sulfoxide; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; 2: modified Pfitzner-Moffat oxidation;
DOI:10.1021/jm000496v