N-METHYL-N-[4-(TRIFLUOROMETHYL)BENZYL]AMINE

Base Information

• Chemical Name: N-METHYL-N-[4-(TRIFLUOROMETHYL)BENZYL]AMINE
• CAS No.: 90390-11-7
• Molecular Formula: C9H10 F3 N
• Molecular Weight: 189.18
• Hs Code.: 2921499090
• Mol file: 90390-11-7.mol

Synonyms:Methyl(4-trifluoromethylbenzyl)amine;N-Methyl-4-(trifluoromethyl)benzylamine; N-Methyl-N-[4-(Trifluoromethyl)benzyl]amine;N-[4-(Trifluoromethyl)benzyl]-N-methylamine

Chemical Property of N-METHYL-N-[4-(TRIFLUOROMETHYL)BENZYL]AMINE

Chemical Property:

• Vapor Pressure: 0.644mmHg at 25°C
• Boiling Point: 187°Cat760mmHg
• Flash Point: 66.9°C
• PSA: 12.03000
• Density: 1.149g/cm³
• LogP: 2.81570
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-Methyl-n-[4-(trifluoromethyl)benzyl]amine ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38-34-22
• Safety Statements: 26-36/37/39-45-23

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-METHYL-N-[4-(TRIFLUOROMETHYL)BENZYL]AMINE

There total 5 articles about N-METHYL-N-[4-(TRIFLUOROMETHYL)BENZYL]AMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(4-trifluoromethylbenzylidene)methanamine (911101-44-5) → N-Methyl-4-(trifluoromethyl)benzylamine (90390-11-7)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 2h; Heating;

DOI:10.1021/jm00375a005

Reference yield:

4-Trifluoromethylbenzaldehyde (455-19-6) → N-Methyl-4-(trifluoromethyl)benzylamine (90390-11-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1 h / 80 °C

2: LiAlH₄ / diethyl ether / 2 h / Heating

With lithium aluminium tetrahydride; In diethyl ether;

DOI:10.1021/jm00375a005

Reference yield:

methanol (67-56-1) + p-Trifluoromethylbenzylamine (3300-51-4) → N-Methyl-4-(trifluoromethyl)benzylamine (90390-11-7)

Guidance literature:

With carbonylhydrido(tetrahydroborato)[bis(2-diphenylphosphinoethyl)amino]ruthenium(II); hydrogen; at 140 ℃; for 24h; under 30003 Torr; Glovebox;

DOI:10.1002/anie.201801524

upstream raw materials:

N-(4-trifluoromethylbenzylidene)methanamine

N-{[3-(trifluoromethyl)phenyl]methylidene}methanamine

4-Trifluoromethylbenzaldehyde

methanol

Downstream raw materials:

6-[Methyl-(4-trifluoromethyl-benzyl)-amino]-3-nitro-pyridine-2-carbonitrile

3-Amino-6-[methyl-(4-trifluoromethyl-benzyl)-amino]-pyridine-2-carbonitrile

N⁶-Methyl-N⁶-(4-trifluoromethyl-benzyl)-pyrido[3,2-d]pyrimidine-2,4,6-triamine

tert-butyl methyl(4-(trifluoromethyl)benzyl)carbamate

Refernces

• 1、 Merritt, J. Robert,Liu, Jinqi,Quadros, Elizabeth,Morris, Michelle L.,Liu, Ruiyan,Zhang, Rui,Jacob, Biji,Postelnek, Jennifer,Hicks, Catherine M.,Chen, Weiqing,Kimble, Earl F.,Rogers, W. Lynn,O'Brien, Linda,White, Nicole,Desai, Hema,Bansal, Shalini,King, George,Ohlmeyer, Michael J.,Appell, Kenneth C.,Webb, Maria L.. "Novel pyrrolidine ureas as C-C chemokine receptor 1 (CCR1) antagonists". supporting information; experimental part. p. 1295 - 1301. Retrieved 2009/12/07.
• 2、 -. "Imidazole compounds". . . Retrieved 2008/06/13.