(R)-4-(3-{4-[(S)-2-tert-Butoxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-propyl]-phenoxy}-4-methoxy-benzoyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester

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Chemical Name:(R)-4-(3-{4-[(S)-2-tert-Butoxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-propyl]-phenoxy}-4-methoxy-benzoyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester
CAS No.:143817-64-5
Molecular Formula:C₄₁H₅₆N₂O₉Si
Molecular Weight:748.989
Hs Code.:

(R)-4-(3-{4-[(S)-2-tert-Butoxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-propyl]-phenoxy}-4-methoxy-benzoyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester

Synonyms:(R)-4-(3-{4-[(S)-2-tert-Butoxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-propyl]-phenoxy}-4-methoxy-benzoyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester

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Chemical Property of (R)-4-(3-{4-[(S)-2-tert-Butoxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-propyl]-phenoxy}-4-methoxy-benzoyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester

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Technology Process of (R)-4-(3-{4-[(S)-2-tert-Butoxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-propyl]-phenoxy}-4-methoxy-benzoyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester

There total 16 articles about (R)-4-(3-{4-[(S)-2-tert-Butoxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-propyl]-phenoxy}-4-methoxy-benzoyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 143840-96-4
(R)-4-{3-[4-((S)-2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-phenoxy]-4-methoxy-benzoyl}-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester

: 143817-64-5
(R)-4-(3-{4-[(S)-2-tert-Butoxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-propyl]-phenoxy}-4-methoxy-benzoyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester

Guidance literature:: With dmap; triethylamine; In dichloromethane;
DOI:10.1021/jo00048a005

Reference yield:

: 3978-80-1
Boc-Tyr-OH

: 143817-64-5
(S)-4-(3-{4-[(S)-2-tert-Butoxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-propyl]-phenoxy}-4-methoxy-benzoyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 82 percent / LiAlH₄ / diethyl ether

2: 87 percent / p-toluenesulfonic acid / acetone

3: 82 percent / DCC, DMAP

4: 64 percent / Tebbe's reagent / toluene

5: toluene / 120 °C

6: DDQ

7: methanol, p-toluenesulfonic acid / Ambient temperature

8: Et₃N, DMAP / CH₂Cl₂

With methanol; dmap; lithium aluminium tetrahydride; Tebbe's reagent; toluene-4-sulfonic acid; triethylamine; dicyclohexyl-carbodiimide; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In diethyl ether; dichloromethane; acetone; toluene;
DOI:10.1021/jo00048a005

Reference yield:

: 3978-80-1
Boc-Tyr-OH

: 143817-64-5
(R)-4-(3-{4-[(S)-2-tert-Butoxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-propyl]-phenoxy}-4-methoxy-benzoyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 82 percent / LiAlH₄ / diethyl ether

2: 87 percent / p-toluenesulfonic acid / acetone

3: 82 percent / DCC, DMAP

4: 64 percent / Tebbe's reagent / toluene

5: 46 percent / toluene / 120 °C

6: DDQ

7: 68 percent / methanol, p-toluenesulfonic acid / Ambient temperature

8: 100 percent / Et₃N, DMAP / CH₂Cl₂

With methanol; dmap; lithium aluminium tetrahydride; Tebbe's reagent; toluene-4-sulfonic acid; triethylamine; dicyclohexyl-carbodiimide; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In diethyl ether; dichloromethane; acetone; toluene;
DOI:10.1021/jo00048a005