4-{2-[4-(4-(R)-tert-butylcyclohex-1-enyl)phenyl]-2-ethoxycarbonylethyl}benzoic acid tert-butyl ester

Base Information

Chemical Name:4-{2-[4-(4-(R)-tert-butylcyclohex-1-enyl)phenyl]-2-ethoxycarbonylethyl}benzoic acid tert-butyl ester
CAS No.:1207989-59-0
Molecular Formula:C₃₂H₄₂O₄
Molecular Weight:490.683
Hs Code.:

Synonyms:4-{2-[4-(4-(R)-tert-butylcyclohex-1-enyl)phenyl]-2-ethoxycarbonylethyl}benzoic acid tert-butyl ester

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Chemical Property of 4-{2-[4-(4-(R)-tert-butylcyclohex-1-enyl)phenyl]-2-ethoxycarbonylethyl}benzoic acid tert-butyl ester

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Technology Process of 4-{2-[4-(4-(R)-tert-butylcyclohex-1-enyl)phenyl]-2-ethoxycarbonylethyl}benzoic acid tert-butyl ester

There total 6 articles about 4-{2-[4-(4-(R)-tert-butylcyclohex-1-enyl)phenyl]-2-ethoxycarbonylethyl}benzoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1207989-56-7
[4-((R)-4-tert-butylcyclohex-1-enyl)phenyl]acetic acid ethyl ester

: 108052-76-2
4-(bromomethyl)benzoic acid 1,1-dimethylethyl ester

: 1207989-59-0
4-{2-[4-(4-(R)-tert-butylcyclohex-1-enyl)phenyl]-2-ethoxycarbonylethyl}benzoic acid tert-butyl ester

Guidance literature:: [4-((R)-4-tert-butylcyclohex-1-enyl)phenyl]acetic acid ethyl ester; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h;

4-(bromomethyl)benzoic acid 1,1-dimethylethyl ester; In tetrahydrofuran; at -78 - 20 ℃;

Reference yield:

: 14062-25-0
Ethyl 4-bromophenylacetate

: 1207989-59-0
4-{2-[4-(4-(R)-tert-butylcyclohex-1-enyl)phenyl]-2-ethoxycarbonylethyl}benzoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: dichlorobis(tri-O-tolylphosphine)palladium; sodium carbonate / tetrahydrofuran; ethanol; water / 0.08 h / 140 °C

2: AD mix-β; methanesulfonamide / water; tert-butyl alcohol / 96 h / 2 - 4 °C

3: tetrahydrofuran / Reflux; Inert atmosphere

4: triethyl phosphite / 150 °C / Reflux

5: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

With dichlorobis(tri-O-tolylphosphine)palladium; methanesulfonamide; AD mix-β; sodium carbonate; lithium hexamethyldisilazane; triethyl phosphite; In tetrahydrofuran; ethanol; water; tert-butyl alcohol;

Reference yield:

: [4-((3R,6R,7R)-6-tert-butyl-2-thioxotetrahydrobenzo[1,3]dioxol-3-yl)phenyl]acetic acid ethyl ester

: 1207989-59-0
4-{2-[4-(4-(R)-tert-butylcyclohex-1-enyl)phenyl]-2-ethoxycarbonylethyl}benzoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: triethyl phosphite / 150 °C / Reflux

2: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

With lithium hexamethyldisilazane; triethyl phosphite; In tetrahydrofuran;