4-{2-[4-(4-(R)-tert-butylcyclohex-1-enyl)phenyl]-2-(4'-chloro-2'-methylbiphenyl-4-ylcarbamoyl)ethyl}benzoic acid tert-butyl ester

Base Information

Chemical Name:4-{2-[4-(4-(R)-tert-butylcyclohex-1-enyl)phenyl]-2-(4'-chloro-2'-methylbiphenyl-4-ylcarbamoyl)ethyl}benzoic acid tert-butyl ester
CAS No.:1207989-66-9
Molecular Formula:C₄₃H₄₈ClNO₃
Molecular Weight:662.312
Hs Code.:

Synonyms:4-{2-[4-(4-(R)-tert-butylcyclohex-1-enyl)phenyl]-2-(4'-chloro-2'-methylbiphenyl-4-ylcarbamoyl)ethyl}benzoic acid tert-butyl ester

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Chemical Property of 4-{2-[4-(4-(R)-tert-butylcyclohex-1-enyl)phenyl]-2-(4'-chloro-2'-methylbiphenyl-4-ylcarbamoyl)ethyl}benzoic acid tert-butyl ester

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Technology Process of 4-{2-[4-(4-(R)-tert-butylcyclohex-1-enyl)phenyl]-2-(4'-chloro-2'-methylbiphenyl-4-ylcarbamoyl)ethyl}benzoic acid tert-butyl ester

There total 10 articles about 4-{2-[4-(4-(R)-tert-butylcyclohex-1-enyl)phenyl]-2-(4'-chloro-2'-methylbiphenyl-4-ylcarbamoyl)ethyl}benzoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1207989-35-2
4′-chloro-2′-methylbiphenyl-4-amine

: 1207989-63-6
4-{2-[4-(4-(R)-tert-butylcyclohex-1-enyl)phenyl]-2-carboxyethyl}benzoic acid tert-butyl ester

: 1207989-66-9
4-{2-[4-(4-(R)-tert-butylcyclohex-1-enyl)phenyl]-2-(4'-chloro-2'-methylbiphenyl-4-ylcarbamoyl)ethyl}benzoic acid tert-butyl ester

Guidance literature:: 4-{2-[4-(4-(R)-tert-butylcyclohex-1-enyl)phenyl]-2-carboxyethyl}benzoic acid tert-butyl ester; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 1h;

4′-chloro-2′-methylbiphenyl-4-amine; With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 1.5h; Reflux;

Reference yield:

: 540-37-4
p-aminoiodobenzene

: 1207989-66-9
4-{2-[4-(4-(R)-tert-butylcyclohex-1-enyl)phenyl]-2-(4'-chloro-2'-methylbiphenyl-4-ylcarbamoyl)ethyl}benzoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: dichlorobis(tri-O-tolylphosphine)palladium; sodium carbonate / ethanol; water; 1,2-dimethoxyethane / 2 h / 125 °C

2.1: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 1 h / 20 °C

2.2: 1.5 h / Reflux

With oxalyl dichloride; dichlorobis(tri-O-tolylphosphine)palladium; sodium carbonate; In 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1207989-44-3
[4-(4-tert-butylcyclohex-1-enyl)phenyl]acetic acid ethyl ester

: 1207989-66-9
4-{2-[4-(4-(R)-tert-butylcyclohex-1-enyl)phenyl]-2-(4'-chloro-2'-methylbiphenyl-4-ylcarbamoyl)ethyl}benzoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: AD mix-β; methanesulfonamide / water; tert-butyl alcohol / 96 h / 2 - 4 °C

2.1: tetrahydrofuran / Reflux; Inert atmosphere

3.1: triethyl phosphite / 150 °C / Reflux

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

5.1: lithium hydroxide; water / tetrahydrofuran; methanol / 5 h / 20 °C

6.1: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 1 h / 20 °C

6.2: 1.5 h / Reflux

With oxalyl dichloride; methanesulfonamide; AD mix-β; water; lithium hydroxide; lithium hexamethyldisilazane; triethyl phosphite; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;