N-(3-(4-(4-chloro-2-methylphenyl)-5-(5-chloro-2-methylphenyl)-3-isopropyl-6-oxo-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-d]pyrimidin-2-yl)-4-methoxybenzyl)formamide

Base Information

Chemical Name:N-(3-(4-(4-chloro-2-methylphenyl)-5-(5-chloro-2-methylphenyl)-3-isopropyl-6-oxo-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-d]pyrimidin-2-yl)-4-methoxybenzyl)formamide
CAS No.:1620845-16-0
Molecular Formula:C₃₁H₃₁Cl₂N₅O₃
Molecular Weight:592.525
Hs Code.:

N-(3-(4-(4-chloro-2-methylphenyl)-5-(5-chloro-2-methylphenyl)-3-isopropyl-6-oxo-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-d]pyrimidin-2-yl)-4-methoxybenzyl)formamide

Synonyms:N-(3-(4-(4-chloro-2-methylphenyl)-5-(5-chloro-2-methylphenyl)-3-isopropyl-6-oxo-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-d]pyrimidin-2-yl)-4-methoxybenzyl)formamide

Suppliers and Price of N-(3-(4-(4-chloro-2-methylphenyl)-5-(5-chloro-2-methylphenyl)-3-isopropyl-6-oxo-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-d]pyrimidin-2-yl)-4-methoxybenzyl)formamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-(3-(4-(4-chloro-2-methylphenyl)-5-(5-chloro-2-methylphenyl)-3-isopropyl-6-oxo-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-d]pyrimidin-2-yl)-4-methoxybenzyl)formamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(3-(4-(4-chloro-2-methylphenyl)-5-(5-chloro-2-methylphenyl)-3-isopropyl-6-oxo-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-d]pyrimidin-2-yl)-4-methoxybenzyl)formamide

There total 13 articles about N-(3-(4-(4-chloro-2-methylphenyl)-5-(5-chloro-2-methylphenyl)-3-isopropyl-6-oxo-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-d]pyrimidin-2-yl)-4-methoxybenzyl)formamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.9%

: 64-18-6
formic acid

: 1620845-14-8
2-(5-(aminomethyl)-2-methoxyphenyl)-4-(4-chloro-2-methylphenyl)-5-(5-chloro-2-methylphenyl)-3-isopropyl-4,5-dihydro-2H-pyrazolo[3,4-d]pyrimidin-6(7H)-one

: 1620845-16-0
N-(3-(4-(4-chloro-2-methylphenyl)-5-(5-chloro-2-methylphenyl)-3-isopropyl-6-oxo-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-d]pyrimidin-2-yl)-4-methoxybenzyl)formamide

Guidance literature:: With 4-methyl-morpholine; dmap; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; In dichloromethane; at 45 ℃; for 20h; Inert atmosphere;

Reference yield:

: 64195-85-3
ethyl 2,4-dioxo-5-methylhexanoate

: 1620845-16-0
N-(3-(4-(4-chloro-2-methylphenyl)-5-(5-chloro-2-methylphenyl)-3-isopropyl-6-oxo-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-d]pyrimidin-2-yl)-4-methoxybenzyl)formamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: toluene / 1 h / 110 °C / Inert atmosphere

2.1: bromine / dichloromethane / 3 h / 20 °C / Irradiation

3.1: potassium carbonate; bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 80 °C / Inert atmosphere

4.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / 1,4-dioxane; water; tert-butyl alcohol / 20 h / 20 °C

4.2: 2 h / 20 °C

5.1: tetrahydrofuran / 0.25 h / -10 °C / Inert atmosphere

6.1: triethylamine; Methanesulfonic anhydride / dichloromethane / 1 h / 20 °C / Inert atmosphere

6.2: 1 h / 20 °C / Inert atmosphere

7.1: lithium hydroxide monohydrate / 1,4-dioxane; water / 50 °C

8.1: diphenyl phosphoryl azide; triethylamine / 1,2-dimethoxyethane / 2 h / 85 °C / Inert atmosphere

9.1: hydrogen; ammonia / methanol / 16 h / 20 °C

10.1: 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; dmap; 4-methyl-morpholine / dichloromethane / 20 h / 45 °C / Inert atmosphere

With 4-methyl-morpholine; dmap; osmium(VIII) oxide; bis(tri-t-butylphosphine)palladium⁽⁰⁾; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; lithium hydroxide monohydrate; diphenyl phosphoryl azide; ammonia; hydrogen; bromine; potassium carbonate; 4-methylmorpholine N-oxide; triethylamine; Methanesulfonic anhydride; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; water; toluene; tert-butyl alcohol;

Reference yield:

: 1441756-22-4
4-[(4-chloro-2-methyl-phenyl)-(5-chloro-2-methyl-phenylamino)-methyl]-1-(5-cyano-2-methoxy-phenyl)-5-isopropyl-1H-pyrazole-3-carboxylic acid

: 1620845-16-0
N-(3-(4-(4-chloro-2-methylphenyl)-5-(5-chloro-2-methylphenyl)-3-isopropyl-6-oxo-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-d]pyrimidin-2-yl)-4-methoxybenzyl)formamide

Guidance literature:: Multi-step reaction with 3 steps

1: diphenyl phosphoryl azide; triethylamine / 1,2-dimethoxyethane / 2 h / 85 °C / Inert atmosphere

2: hydrogen; ammonia / methanol / 16 h / 20 °C

3: 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; dmap; 4-methyl-morpholine / dichloromethane / 20 h / 45 °C / Inert atmosphere

With 4-methyl-morpholine; dmap; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; diphenyl phosphoryl azide; ammonia; hydrogen; triethylamine; In methanol; 1,2-dimethoxyethane; dichloromethane;