ethyl 3-phenyl-3-(trimethylsiloxycarbonylamino)propanoate

Base Information

• Chemical Name: ethyl 3-phenyl-3-(trimethylsiloxycarbonylamino)propanoate
• CAS No.: 1021464-42-5
• Molecular Formula: C₁₅H₂₃NO₄Si
• Molecular Weight: 309.437
• Mol file: 1021464-42-5.mol

Synonyms:ethyl 3-phenyl-3-(trimethylsiloxycarbonylamino)propanoate

Chemical Property of ethyl 3-phenyl-3-(trimethylsiloxycarbonylamino)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 3-phenyl-3-(trimethylsiloxycarbonylamino)propanoate

There total 3 articles about ethyl 3-phenyl-3-(trimethylsiloxycarbonylamino)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

carbon dioxide (124-38-9,18923-20-1) + ethyl 3-amino-3-phenylpropanoate hydrochloride (29754-04-9,340188-50-3) + 1,1,1,3,3,3-hexamethyl-disilazane (999-97-3) → ethyl 3-phenyl-3-(trimethylsiloxycarbonylamino)propanoate (1021464-42-5) + C18H31O4NSi2 + N,O-bis<(trimethylsilyl)oxy>acetamide (35342-88-2)

Guidance literature:

for 5h; Title compound not separated from byproducts.; Heating;

DOI:10.1134/S1070363206070115

Reference yield:

3-Amino-3-phenylpropionic acid (3646-50-2) → ethyl 3-phenyl-3-(trimethylsiloxycarbonylamino)propanoate (1021464-42-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 98.7 percent / Me₃SiCl / Heating

2: toluene / 5 h / 90 - 95 °C

With chloro-trimethyl-silane; In toluene;

DOI:10.1134/S1070363207040135

Reference yield:

carbon dioxide (124-38-9,18923-20-1) + ethyl 3-amino-3-phenylpropanoate hydrochloride (29754-04-9,340188-50-3) + 1,1,1,3,3,3-hexamethyl-disilazane (999-97-3) → ethyl 3-phenyl-3-(trimethylsiloxycarbonylamino)propanoate (1021464-42-5)

Guidance literature:

In toluene; at 90 - 95 ℃; for 5h;

DOI:10.1134/S1070363207040135

upstream raw materials:

carbon dioxide

ethyl 3-amino-3-phenylpropanoate hydrochloride

1,1,1,3,3,3-hexamethyl-disilazane

3-Amino-3-phenylpropionic acid

Downstream raw materials:

ethyl 3-phenyl-3-isocyanatopropanoate