(S)-3-Methyl-4-[(S)-2-phenyl-1-(4-trifluoromethyl-phenyl)-ethyl]-piperazine-1-carboxylic acid tert-butyl ester

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Chemical Name:(S)-3-Methyl-4-[(S)-2-phenyl-1-(4-trifluoromethyl-phenyl)-ethyl]-piperazine-1-carboxylic acid tert-butyl ester
CAS No.:306298-08-8
Molecular Formula:C₂₅H₃₁F₃N₂O₂
Molecular Weight:448.529
Hs Code.:

Synonyms:(S)-3-Methyl-4-[(S)-2-phenyl-1-(4-trifluoromethyl-phenyl)-ethyl]-piperazine-1-carboxylic acid tert-butyl ester

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Chemical Property of (S)-3-Methyl-4-[(S)-2-phenyl-1-(4-trifluoromethyl-phenyl)-ethyl]-piperazine-1-carboxylic acid tert-butyl ester

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Technology Process of (S)-3-Methyl-4-[(S)-2-phenyl-1-(4-trifluoromethyl-phenyl)-ethyl]-piperazine-1-carboxylic acid tert-butyl ester

There total 5 articles about (S)-3-Methyl-4-[(S)-2-phenyl-1-(4-trifluoromethyl-phenyl)-ethyl]-piperazine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 306298-07-7
4-[1-cyano-2-phenyl-1-(4-trifluoromethyl-phenyl)-ethyl]-3-methyl-piperazine-1-carboxylic acid tert-butyl ester

: 306298-08-8
(S)-3-Methyl-4-[(S)-2-phenyl-1-(4-trifluoromethyl-phenyl)-ethyl]-piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: With sodium tris(acetoxy)borohydride; magnesium bromide; In acetonitrile;
DOI:10.1021/jm0304515

Reference yield:

: 306298-07-7
4-[1-cyano-2-phenyl-1-(4-trifluoromethyl-phenyl)-ethyl]-3-methyl-piperazine-1-carboxylic acid tert-butyl ester

: C₂₅H₃₁F₃N₂O₂

: 306298-08-8
(S)-3-Methyl-4-[(S)-2-phenyl-1-(4-trifluoromethyl-phenyl)-ethyl]-piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: With magnesium bromide diethyl etherate; sodium tris(acetoxy)borohydride; In acetonitrile; at 20 ℃; for 70h;

Reference yield:

: 455-19-6
4-Trifluoromethylbenzaldehyde

: 306298-08-8
(S)-3-Methyl-4-[(S)-2-phenyl-1-(4-trifluoromethyl-phenyl)-ethyl]-piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: titanium isopropoxide / 3 h

1.2: 85 percent / toluene / 20 h / 20 °C

2.1: sodium hexamethyldisilazide / tetrahydrofuran

2.2: tetrahydrofuran / 20 °C

3.1: 36 percent / MgBr₂*OEt₂; sodium triacetoxy borohydride / acetonitrile

With titanium(IV) isopropylate; sodium hexamethyldisilazane; sodium tris(acetoxy)borohydride; magnesium bromide; In tetrahydrofuran; acetonitrile;
DOI:10.1021/jm0304515