(+)-5-[3’,5’-bis(trifluoromethyl)phenyl]-8,10,10-trimethyl-6-azatricyclo[7.1.1.02,7]undeca-2(7),3,5-triene

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Chemical Name:(+)-5-[3’,5’-bis(trifluoromethyl)phenyl]-8,10,10-trimethyl-6-azatricyclo[7.1.1.02,7]undeca-2(7),3,5-triene
CAS No.:1448527-73-8
Molecular Formula:C₂₁H₁₉F₆N
Molecular Weight:399.379
Hs Code.:

Synonyms:(+)-5-[3’,5’-bis(trifluoromethyl)phenyl]-8,10,10-trimethyl-6-azatricyclo[7.1.1.02,7]undeca-2(7),3,5-triene

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Chemical Property of (+)-5-[3’,5’-bis(trifluoromethyl)phenyl]-8,10,10-trimethyl-6-azatricyclo[7.1.1.02,7]undeca-2(7),3,5-triene

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Technology Process of (+)-5-[3’,5’-bis(trifluoromethyl)phenyl]-8,10,10-trimethyl-6-azatricyclo[7.1.1.02,7]undeca-2(7),3,5-triene

There total 3 articles about (+)-5-[3’,5’-bis(trifluoromethyl)phenyl]-8,10,10-trimethyl-6-azatricyclo[7.1.1.02,7]undeca-2(7),3,5-triene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1448527-67-0
1-{2-[3’,5’-bis(trifluoromethyl)phenyl]-2-oxoethyl}pyridinium iodide

: 1448527-35-2
C₁₁H₁₆O

: 1448527-73-8
(+)-5-[3’,5’-bis(trifluoromethyl)phenyl]-8,10,10-trimethyl-6-azatricyclo[7.1.1.02,7]undeca-2(7),3,5-triene

Guidance literature:: 1-{2-[3’,5’-bis(trifluoromethyl)phenyl]-2-oxoethyl}pyridinium iodide; With ammonium acetate; In acetic acid; at 110 ℃; Inert atmosphere;

C₁₁H₁₆O; In acetic acid; at 110 ℃; for 48h; diastereoselective reaction; Inert atmosphere;
DOI:10.1002/chem.201203817

Reference yield:

: 1196-00-5,2734-31-8,19889-94-2,19889-95-3,25465-65-0,25465-95-6,27779-29-9,35997-96-7,35998-01-7,36129-11-0,51152-11-5,73366-08-2,125473-76-9,473-61-0,24041-60-9
(+)-isopinocampheol

: 1448527-73-8
(+)-5-[3’,5’-bis(trifluoromethyl)phenyl]-8,10,10-trimethyl-6-azatricyclo[7.1.1.02,7]undeca-2(7),3,5-triene

Guidance literature:: Multi-step reaction with 2 steps

1.1: propionic acid; sodium ethanolate / Inert atmosphere

1.2: Inert atmosphere

2.1: ammonium acetate / acetic acid / 110 °C / Inert atmosphere

2.2: 48 h / 110 °C / Inert atmosphere

With ammonium acetate; sodium ethanolate; propionic acid; In acetic acid; 2.1: |Kroehnke Pyridine Synthesis / 2.2: |Kroehnke Pyridine Synthesis;
DOI:10.1002/chem.201203817

Reference yield:

: 30071-93-3
3,5-bis(trifluoromethyl)phenyl methyl ketone

: 1448527-73-8
(+)-5-[3’,5’-bis(trifluoromethyl)phenyl]-8,10,10-trimethyl-6-azatricyclo[7.1.1.02,7]undeca-2(7),3,5-triene

Guidance literature:: Multi-step reaction with 2 steps

1.1: iodine / 1 h / Reflux; Inert atmosphere

2.1: ammonium acetate / acetic acid / 110 °C / Inert atmosphere

2.2: 48 h / 110 °C / Inert atmosphere

With ammonium acetate; iodine; In acetic acid; 2.1: |Kroehnke Pyridine Synthesis / 2.2: |Kroehnke Pyridine Synthesis;
DOI:10.1002/chem.201203817