(-)-5-[3’,5’-bis(trifluoromethyl)phenyl]-8,10,10-trimethyl-6-azatricyclo[7.1.1.02,7]undeca-2(7),3,5-triene 6-oxide

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Chemical Name:(-)-5-[3’,5’-bis(trifluoromethyl)phenyl]-8,10,10-trimethyl-6-azatricyclo[7.1.1.02,7]undeca-2(7),3,5-triene 6-oxide
CAS No.:1448527-33-0
Molecular Formula:C₂₁H₁₉F₆NO
Molecular Weight:415.378
Hs Code.:

Synonyms:(-)-5-[3’,5’-bis(trifluoromethyl)phenyl]-8,10,10-trimethyl-6-azatricyclo[7.1.1.02,7]undeca-2(7),3,5-triene 6-oxide

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Chemical Property of (-)-5-[3’,5’-bis(trifluoromethyl)phenyl]-8,10,10-trimethyl-6-azatricyclo[7.1.1.02,7]undeca-2(7),3,5-triene 6-oxide

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Technology Process of (-)-5-[3’,5’-bis(trifluoromethyl)phenyl]-8,10,10-trimethyl-6-azatricyclo[7.1.1.02,7]undeca-2(7),3,5-triene 6-oxide

There total 4 articles about (-)-5-[3’,5’-bis(trifluoromethyl)phenyl]-8,10,10-trimethyl-6-azatricyclo[7.1.1.02,7]undeca-2(7),3,5-triene 6-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1448527-73-8
(+)-5-[3’,5’-bis(trifluoromethyl)phenyl]-8,10,10-trimethyl-6-azatricyclo[7.1.1.02,7]undeca-2(7),3,5-triene

: 1448527-33-0
(-)-5-[3’,5’-bis(trifluoromethyl)phenyl]-8,10,10-trimethyl-6-azatricyclo[7.1.1.02,7]undeca-2(7),3,5-triene 6-oxide

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 - 20 ℃; for 2h; Inert atmosphere;
DOI:10.1002/chem.201203817

Reference yield:

: 1196-00-5,2734-31-8,19889-94-2,19889-95-3,25465-65-0,25465-95-6,27779-29-9,35997-96-7,35998-01-7,36129-11-0,51152-11-5,73366-08-2,125473-76-9,473-61-0,24041-60-9
(+)-isopinocampheol

: 1448527-33-0
(-)-5-[3’,5’-bis(trifluoromethyl)phenyl]-8,10,10-trimethyl-6-azatricyclo[7.1.1.02,7]undeca-2(7),3,5-triene 6-oxide

Guidance literature:: Multi-step reaction with 3 steps

1.1: propionic acid; sodium ethanolate / Inert atmosphere

1.2: Inert atmosphere

2.1: ammonium acetate / acetic acid / 110 °C / Inert atmosphere

2.2: 48 h / 110 °C / Inert atmosphere

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

With ammonium acetate; sodium ethanolate; propionic acid; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; acetic acid; 2.1: |Kroehnke Pyridine Synthesis / 2.2: |Kroehnke Pyridine Synthesis;
DOI:10.1002/chem.201203817

Reference yield:

: 30071-93-3
3,5-bis(trifluoromethyl)phenyl methyl ketone

: 1448527-33-0
(-)-5-[3’,5’-bis(trifluoromethyl)phenyl]-8,10,10-trimethyl-6-azatricyclo[7.1.1.02,7]undeca-2(7),3,5-triene 6-oxide

Guidance literature:: Multi-step reaction with 3 steps

1.1: iodine / 1 h / Reflux; Inert atmosphere

2.1: ammonium acetate / acetic acid / 110 °C / Inert atmosphere

2.2: 48 h / 110 °C / Inert atmosphere

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

With ammonium acetate; iodine; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; acetic acid; 2.1: |Kroehnke Pyridine Synthesis / 2.2: |Kroehnke Pyridine Synthesis;
DOI:10.1002/chem.201203817