1-{2-[3’,5’-bis(trifluoromethyl)phenyl]-2-oxoethyl}pyridinium iodide

Base Information

• Chemical Name: 1-{2-[3’,5’-bis(trifluoromethyl)phenyl]-2-oxoethyl}pyridinium iodide
• CAS No.: 1448527-67-0
• Molecular Formula: C₁₅H₁₀F₆NO*I
• Molecular Weight: 461.145
• Mol file: 1448527-67-0.mol

Synonyms:1-{2-[3’,5’-bis(trifluoromethyl)phenyl]-2-oxoethyl}pyridinium iodide

Chemical Property of 1-{2-[3’,5’-bis(trifluoromethyl)phenyl]-2-oxoethyl}pyridinium iodide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-{2-[3’,5’-bis(trifluoromethyl)phenyl]-2-oxoethyl}pyridinium iodide

There total 1 articles about 1-{2-[3’,5’-bis(trifluoromethyl)phenyl]-2-oxoethyl}pyridinium iodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

pyridine (110-86-1) + 3,5-bis(trifluoromethyl)phenyl methyl ketone (30071-93-3) → 1-{2-[3’,5’-bis(trifluoromethyl)phenyl]-2-oxoethyl}pyridinium iodide (1448527-67-0)

Guidance literature:

With iodine; for 1h; Reflux; Inert atmosphere;

DOI:10.1002/chem.201203817

Reference yield: 76.0%

myrtenal (23727-16-4) + 1-{2-[3’,5’-bis(trifluoromethyl)phenyl]-2-oxoethyl}pyridinium iodide (1448527-67-0) → (6S,8S)-3-(3,5-bis(trifluoromethyl)phenyl)-7,7-dimethyl-5,6,7,8-tetrahydro-6-methanoisoquinoline

Guidance literature:

1-{2-[3’,5’-bis(trifluoromethyl)phenyl]-2-oxoethyl}pyridinium iodide; With ammonium acetate; In formamide; at 50 ℃; for 0.5h; Inert atmosphere;

myrtenal; In formamide; at 100 ℃; for 15h; Inert atmosphere;

DOI:10.1002/chem.201500176

Reference yield: 45.0%

1-{2-[3’,5’-bis(trifluoromethyl)phenyl]-2-oxoethyl}pyridinium iodide (1448527-67-0) + myrtenal (564-94-3,18486-69-6) → (6R,8R)-3-(3,5-bis(trifluoromethyl)phenyl)-7,7-dimethyl-5,6,7,8-tetrahydro-6,8-methanoisoquinoline

Guidance literature:

1-{2-[3’,5’-bis(trifluoromethyl)phenyl]-2-oxoethyl}pyridinium iodide; With ammonium acetate; In formamide; at 50 ℃; for 0.5h;

myrtenal; In formamide; at 100 ℃; for 12h;

DOI:10.1021/acs.orglett.9b01687

upstream raw materials:

pyridine

3,5-bis(trifluoromethyl)phenyl methyl ketone

Downstream raw materials:

(+)-5-[3’,5’-bis(trifluoromethyl)phenyl]-8,10,10-trimethyl-6-azatricyclo[7.1.1.02,7]undeca-2(7),3,5-triene

(-)-5-[3’,5’-bis(trifluoromethyl)phenyl]-8,10,10-trimethyl-6-azatricyclo[7.1.1.02,7]undeca-2(7),3,5-triene 6-oxide