5'-O-2-(2-nitrophenyl)propoxycarbonyl-2'-O-acetal levulinyl ester uridine-3'-O-2-cyanoethyl N,N-diisopropyl phosphoramidite

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Chemical Name:5'-O-2-(2-nitrophenyl)propoxycarbonyl-2'-O-acetal levulinyl ester uridine-3'-O-2-cyanoethyl N,N-diisopropyl phosphoramidite
CAS No.:1161570-47-3
Molecular Formula:C₃₄H₄₆N₅O₁₄P
Molecular Weight:779.738
Hs Code.:

Synonyms:5'-O-2-(2-nitrophenyl)propoxycarbonyl-2'-O-acetal levulinyl ester uridine-3'-O-2-cyanoethyl N,N-diisopropyl phosphoramidite

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Chemical Property of 5'-O-2-(2-nitrophenyl)propoxycarbonyl-2'-O-acetal levulinyl ester uridine-3'-O-2-cyanoethyl N,N-diisopropyl phosphoramidite

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Technology Process of 5'-O-2-(2-nitrophenyl)propoxycarbonyl-2'-O-acetal levulinyl ester uridine-3'-O-2-cyanoethyl N,N-diisopropyl phosphoramidite

There total 3 articles about 5'-O-2-(2-nitrophenyl)propoxycarbonyl-2'-O-acetal levulinyl ester uridine-3'-O-2-cyanoethyl N,N-diisopropyl phosphoramidite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1161570-22-4
5'-O-2-(2-nitrophenyl)propoxycarbonyl-2'-O-acetal levulinyl ester uridine

: 124482-92-4,89992-70-1
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

: 1161570-47-3
5'-O-2-(2-nitrophenyl)propoxycarbonyl-2'-O-acetal levulinyl ester uridine-3'-O-2-cyanoethyl N,N-diisopropyl phosphoramidite

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; for 2h; Inert atmosphere;

Reference yield:

: 174497-93-9
2'-O-methylthiomethyl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

: 1161570-47-3
5'-O-2-(2-nitrophenyl)propoxycarbonyl-2'-O-acetal levulinyl ester uridine-3'-O-2-cyanoethyl N,N-diisopropyl phosphoramidite

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuryl dichloride / benzene; dichloromethane / 0.75 h / 0 - 20 °C / Inert atmosphere

1.2: 2 h / Inert atmosphere

2.1: triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 2 h / Inert atmosphere

3.1: pyridine / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / Inert atmosphere

With pyridine; sulfuryl dichloride; triethylamine tris(hydrogen fluoride); N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; benzene;

Reference yield:

: 1145997-22-3
3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2'-O-acetal levulinyl ester uridine

: 1161570-47-3
5'-O-2-(2-nitrophenyl)propoxycarbonyl-2'-O-acetal levulinyl ester uridine-3'-O-2-cyanoethyl N,N-diisopropyl phosphoramidite

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 2 h / Inert atmosphere

2: pyridine / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / Inert atmosphere

With pyridine; triethylamine tris(hydrogen fluoride); N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;