dimethylcarbamic acid 3-(3-methylaminosulfonylamino-2-fluoro-benzyl)-4-methyl-2-oxo-2H-1-benzopyran-7-yl ester

Base Information

Chemical Name:dimethylcarbamic acid 3-(3-methylaminosulfonylamino-2-fluoro-benzyl)-4-methyl-2-oxo-2H-1-benzopyran-7-yl ester
CAS No.:946128-33-2
Molecular Formula:C₂₁H₂₂FN₃O₆S
Molecular Weight:463.487
Hs Code.:

Synonyms:dimethylcarbamic acid 3-(3-methylaminosulfonylamino-2-fluoro-benzyl)-4-methyl-2-oxo-2H-1-benzopyran-7-yl ester

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Chemical Property of dimethylcarbamic acid 3-(3-methylaminosulfonylamino-2-fluoro-benzyl)-4-methyl-2-oxo-2H-1-benzopyran-7-yl ester

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Technology Process of dimethylcarbamic acid 3-(3-methylaminosulfonylamino-2-fluoro-benzyl)-4-methyl-2-oxo-2H-1-benzopyran-7-yl ester

There total 7 articles about dimethylcarbamic acid 3-(3-methylaminosulfonylamino-2-fluoro-benzyl)-4-methyl-2-oxo-2H-1-benzopyran-7-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 946126-25-6
dimethylcarbamic acid 2-oxo-2H-3-(2-fluoro-3-aminobenzyl)-4-methyl-1-benzopyran-7-yl ester

: 10438-96-7
N-methylsulfamoyl chloride

: 946128-33-2
dimethylcarbamic acid 3-(3-methylaminosulfonylamino-2-fluoro-benzyl)-4-methyl-2-oxo-2H-1-benzopyran-7-yl ester

Guidance literature:: With pyridine; In N,N-dimethyl-formamide; acetonitrile; at 0 - 20 ℃;

Reference yield:

: 946130-13-8
3-(2-fluoro-3-nitrobenzyl)-7-hydroxy-4-methyl-2-oxo-2H-1-benzopyran

: 946128-33-2
dimethylcarbamic acid 3-(3-methylaminosulfonylamino-2-fluoro-benzyl)-4-methyl-2-oxo-2H-1-benzopyran-7-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran; ethanol / 20 °C

3.1: pyridine / acetonitrile; N,N-dimethyl-formamide / 0 - 20 °C

With pyridine; palladium 10% on activated carbon; hydrogen; sodium hydride; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; acetonitrile; mineral oil;

Reference yield:

: 437-86-5
2-fluoro-3-nitrotoluene

: 946128-33-2
dimethylcarbamic acid 3-(3-methylaminosulfonylamino-2-fluoro-benzyl)-4-methyl-2-oxo-2H-1-benzopyran-7-yl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1,1'-azobis(1-cyanocyclohexanenitrile); N-Bromosuccinimide / acetonitrile / 16 h / 80 °C / Inert atmosphere

2.1: sodium iodide; lithium tert-butoxide / tetrahydrofuran / 16 h / 20 °C

3.1: perchloric acid / 18 h / 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C / Inert atmosphere

4.2: 20 °C / Inert atmosphere

5.1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran; ethanol / 20 °C

6.1: pyridine / acetonitrile; N,N-dimethyl-formamide / 0 - 20 °C

With pyridine; N-Bromosuccinimide; perchloric acid; palladium 10% on activated carbon; hydrogen; sodium hydride; sodium iodide; lithium tert-butoxide; 1,1'-azobis(1-cyanocyclohexanenitrile); In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; acetonitrile; mineral oil;