4-(Methylsulfonyl)cyclohexanone

Base Information

• Chemical Name: 4-(Methylsulfonyl)cyclohexanone
• CAS No.: 862129-72-4
• Molecular Formula: C₇H₁₂O₃S
• Molecular Weight: 176.236
• Mol file: 862129-72-4.mol

Synonyms:4-(methylsulfonyl)cyclohexan-1-one

Chemical Property of 4-(Methylsulfonyl)cyclohexanone

Chemical Property:

• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

4-Methylsulfonylcyclohexanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Methylsulfonylcyclohexanone is a reactant used in the preparation of piperidine derivatives as selective estrogen receptor modulators (SERMs) for the potential treatment of uterine fibroids.

Technology Process of 4-(Methylsulfonyl)cyclohexanone

There total 9 articles about 4-(Methylsulfonyl)cyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-trimethylsilyloxy-1,3-butadiene (38053-91-7) + methyl ethenyl sulphone (3680-02-2) → 4-(methylsulfonyl)cyclohexan-1-one (862129-72-4)

Guidance literature:

2-trimethylsilyloxy-1,3-butadiene; methyl ethenyl sulphone; With hydroquinone; In benzene; at -78 - 105 ℃; for 168h; Sealed tube; Inert atmosphere;

With hydrogenchloride; In acetone; at 0 ℃; for 0.25h;

Reference yield: 86.0%

8-(methylsulfonyl)-1,4-dioxaspiro[4.5]decane → 4-(methylsulfonyl)cyclohexan-1-one (862129-72-4)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; for 48h;

Reference yield:

4-(methylthio)cyclohexan-1-one (23510-98-7) → 4-(methylsulfonyl)cyclohexan-1-one (862129-72-4)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at -5 - 5 ℃; for 1.75h;

upstream raw materials:

4,4-ethylenedioxycyclohexan-1-ol

toluene-4-sulfonic acid 1,4-dioxa-spiro[4.5]dec-8-yl ester

8-(methylthio)-1,4-dioxaspiro[4.5]decane

2-trimethylsilyloxy-1,3-butadiene

Downstream raw materials:

(+/-)-trifluoro-methanesulfonic acid 4-methanesulfonyl-cyclohex-1-enyl ester

7-benzyl-7-azabicyclo[2.2.1]heptane-1-carbonitrile