(+/-)-trifluoro-methanesulfonic acid 4-methanesulfonyl-cyclohex-1-enyl ester

Base Information

• Chemical Name: (+/-)-trifluoro-methanesulfonic acid 4-methanesulfonyl-cyclohex-1-enyl ester
• CAS No.: 862129-73-5
• Molecular Formula: C₈H₁₁F₃O₅S₂
• Molecular Weight: 308.3
• Mol file: 862129-73-5.mol

Synonyms:(+/-)-trifluoro-methanesulfonic acid 4-methanesulfonyl-cyclohex-1-enyl ester

Chemical Property of (+/-)-trifluoro-methanesulfonic acid 4-methanesulfonyl-cyclohex-1-enyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-trifluoro-methanesulfonic acid 4-methanesulfonyl-cyclohex-1-enyl ester

There total 2 articles about (+/-)-trifluoro-methanesulfonic acid 4-methanesulfonyl-cyclohex-1-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

4-(methylsulfonyl)cyclohexan-1-one (862129-72-4) + trifluoromethylsulfonic anhydride (358-23-6) → (+/-)-trifluoro-methanesulfonic acid 4-methanesulfonyl-cyclohex-1-enyl ester (862129-73-5)

Guidance literature:

With 2,6-di-tert-butyl-4-methylpyridine; In dichloromethane; for 12h; Heating / reflux;

Reference yield:

C10H20SO3Si → (+/-)-trifluoro-methanesulfonic acid 4-methanesulfonyl-cyclohex-1-enyl ester (862129-73-5)

Guidance literature:

Multi-step reaction with 2 steps

1: TFA / methanol

2: 2,6-di-tert-butyl-4-methylpyridine / CH₂Cl₂

With 2,6-di-tert-butyl-4-methylpyridine; trifluoroacetic acid; In methanol; dichloromethane;

DOI:10.1016/j.bmcl.2007.04.044

Reference yield: 86.0%

(+/-)-trifluoro-methanesulfonic acid 4-methanesulfonyl-cyclohex-1-enyl ester (862129-73-5) + bis(pinacol)diborane (73183-34-3) → (+/-)-2-(4-methanesulfonyl-cyclohex-1-enyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane (862129-71-3)

Guidance literature:

With potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In dimethyl sulfoxide; at 70 ℃; for 12h;

upstream raw materials:

4-(methylsulfonyl)cyclohexan-1-one

trifluoromethylsulfonic anhydride

Downstream raw materials:

(+/-)-2-(4-methanesulfonyl-cyclohex-1-enyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane

6-(4-methanesulfonyl-cyclohexyl)-5-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-naphthalen-2-ol

(+/-)-1-(2-{4-[2-(4-methanesulfonyl-cyclohex-1-enyl)-6-methoxy-naphthalen-1-yloxy]-phenoxy}-ethyl)-piperidine

(+/-)-6-(4-methanesulfonyl-cyclohex-1-enyl)-5-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-naphthalen-2-ol