1,1-DIPHENYL-2-PICRYLHYDRAZYL

Base Information

• Chemical Name: 1,1-DIPHENYL-2-PICRYLHYDRAZYL
• CAS No.: 1898-66-4
• Deprecated CAS: 111051-84-4,56537-16-7
• Molecular Formula: C18H12 N5 O6
• Molecular Weight: 396.339
• Hs Code.: 29280000
• UNII: DFD3H4VGDH
• DSSTox Substance ID: DTXSID90883768
• Mol file: 1898-66-4.mol

Synonyms:Hydrazyl,2,2-diphenyl-1-(2,4,6-trinitrophenyl)- (9CI);Hydrazyl, 2,2-diphenyl-1-picryl-(8CI);1,1-Diphenyl-2-picrylhydrazyl radical;2,2-Diphenyl-1-picrylhydrazyl;2,2-Diphenylpicrylhydrazyl;DPPH;Diphenylpicrylhydrazyl;N,N-Diphenyl-N'-picrylhydrazyl;

Chemical Property of 1,1-DIPHENYL-2-PICRYLHYDRAZYL

Chemical Property:

• Melting Point: ~135 °C (dec.)(lit.)
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 140.70000
• Density: g/cm³
• LogP: 5.97000
• Storage Temp.: 2-8°C
• Solubility.: Acetonitrile (Slightly), Chloroform (Slightly), DMSO (Slightly), Methanol (Sligh
• Water Solubility.: Soluble in dimethyl formamide, ethanol, chloroform, ether, carbon disulfinde, acetone, oils, carbon tetrachloride, glacial aceti
• XLogP3: 5.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 4
• Exact Mass: 394.07875812
• Heavy Atom Count: 29
• Complexity: 549

Purity/Quality:

99% ^*data from raw suppliers

2,2-Diphenyl-1-picrylhydrazyl ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 42/43
• Safety Statements: 22-36/37-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Nitrogen Compounds -> Other Aromatics (Nitrogen)
• Canonical SMILES: C1=CC=C(C=C1)N(C2=CC=CC=C2)[N]C3=C(C=C(C=C3[N+](=O)[O-])[N+](=O)[O-])[N+](=O)[O-]
• Uses: 2,2-Diphenyl-1-picrylhydrazyl is a stable free radical molecule most commonly used as a tool to monitor chemical reactions involving radicals, most notably in antioxidant assay. 2,2-Diphenyl-1-picrylhydrazyl is used as a sensitive colorimetric free radical scavenger. It serves as a general antioxidant detector. It is utilized to monitor chemical reactions involving radicals as well as a standard of the position and intensity of electron paramagnetic resonance signals. Further, it is employed in the quantitative determination of aliphatic and aromatic thiols by indirect spectroscopy and for photometric determination of tocopherol.

Technology Process of 1,1-DIPHENYL-2-PICRYLHYDRAZYL

There total 17 articles about 1,1-DIPHENYL-2-PICRYLHYDRAZYL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2,2-diphenyl-1-picrylhydrazine (1707-75-1) → 2,2-diphenyl-1-(2,4,6-trinitrophenyl)hydrazyl (147506-92-1,1898-66-4)

Guidance literature:

With potassium permanganate; tetrabutylammomium bromide; In dichloromethane; without n-Bu₄NBr, var. solv.: benzene, var. reag.: PbO₂, Na₂SO₄;

Reference yield: 86.7%

α-hydroperoxy-α,α-diphenylacetonitrile (5233-67-0) + 2,2-diphenyl-1-picrylhydrazine (1707-75-1) → 2,2-diphenyl-1-(2,4,6-trinitrophenyl)hydrazyl (147506-92-1,1898-66-4) + 2-hydroxy-2,2-diphenylacetonitrile (4746-48-9)

Guidance literature:

TPP(Cl)Mn^IIIImH; In dichloromethane; at 25 ℃; Rate constant; variation of ImH and DPPH concentration;

DOI:10.1021/ja00267a039

Reference yield: 76.9%

3-chloro-benzenecarboperoxoic acid (937-14-4) + 2,2-diphenyl-1-picrylhydrazine (1707-75-1) → 2,2-diphenyl-1-(2,4,6-trinitrophenyl)hydrazyl (147506-92-1,1898-66-4) + 3-chlorobenzoate (535-80-8)

Guidance literature:

TPP(Cl)Mn^IIIImH; In dichloromethane; at 25 ℃; Rate constant;

DOI:10.1021/ja00267a039

upstream raw materials:

2,2-diphenyl-1-picrylhydrazine

Tetra-tert-butylindophenoxyl

3-chloro-benzenecarboperoxoic acid

4-nitroperbenzoic acid

Downstream raw materials:

naphthalene

2-(p-bromophenyl)-2-phenyl-1-picrylhydrazine

Tetra-tert-butylindophenoxyl

2,2-diphenyl-1-picrylhydrazine

Refernces

Enzymatic synthesis of 1-o-galloylglycerol: Characterization and determination of its antioxidant properties

10.1016/j.foodchem.2019.125479

Siyu Zhang and Casimir C. Akoh investigate the enzymatic synthesis of 1-o-galloylglycerol (GG) using a food-grade lipase (Lipozyme? 435) and optimizes the reaction conditions to achieve a yield of 76.9% ± 1.2%. GG was characterized by various techniques and found to have higher water solubility and hydrophilicity compared to gallic acid (GA) and propyl gallate (PG). The antioxidant properties of GG were evaluated using ferric reducing antioxidant power (FRAP), hydrogen peroxide (H2O2) scavenging, 1,1-diphenyl-2-picrylhydrazyl (DPPH), and 2,2-azinobis (3-ethylbenzthiazoline-6-sulfonic acid) (ABTS+) assays, revealing that GG exhibited superior scavenging capacity compared to GA and PG. The study suggests that GG could serve as a water-soluble antioxidant alternative to GA for food and cosmetic applications, offering enhanced solubility and potentially safer use due to its lower acidity and reduced likelihood of cellular penetration and cytotoxicity.

Synthesis, molecular docking and biological evaluation of 3-arylfuran-2(5H)-ones as anti-gastric ulcer agent

10.1016/j.bmc.2015.05.026

The study focuses on the synthesis, molecular docking, and biological evaluation of 3-Arylfuran-2(5H)-ones as potential anti-gastric ulcer agents. The researchers synthesized twenty derivatives of 3-Arylfuran-2(5H)-ones and assessed their anti-Helicobacter pylori (anti-H. pylori), antioxidant, and urease inhibitory activities, which are crucial for combating H. pylori infections linked to gastritis and peptic ulcers. The results indicated that several compounds showed notable antioxidant and anti-H. pylori activities, with compound b9, 3-(3-methylphenyl)furan-2(5H)-one, demonstrating the most potent antioxidant activity and good anti-H. pylori activity, suggesting its potential as a novel anti-gastric ulcer agent. Additionally, the study explored the compounds' interactions with tyrosyl-tRNA synthetase (TyrRS) through molecular docking, providing insights into their mechanism of action.

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