((R)-Hydroxy-{(1R,2R,3S,4R,5R,6R)-2,3,4,6-tetrakis-benzyloxy-5-[benzyloxy-((R)-2-methoxy-3-octadecyloxy-propoxy)-phosphoryloxy]-cyclohexyl}-methyl)-phosphonic acid dibenzyl ester

Base Information

Chemical Name:((R)-Hydroxy-{(1R,2R,3S,4R,5R,6R)-2,3,4,6-tetrakis-benzyloxy-5-[benzyloxy-((R)-2-methoxy-3-octadecyloxy-propoxy)-phosphoryloxy]-cyclohexyl}-methyl)-phosphonic acid dibenzyl ester
CAS No.:444902-96-9
Molecular Formula:C₇₈H₁₀₂O₁₄P₂
Molecular Weight:1325.61
Hs Code.:

((R)-Hydroxy-{(1R,2R,3S,4R,5R,6R)-2,3,4,6-tetrakis-benzyloxy-5-[benzyloxy-((R)-2-methoxy-3-octadecyloxy-propoxy)-phosphoryloxy]-cyclohexyl}-methyl)-phosphonic acid dibenzyl ester

Synonyms:((R)-Hydroxy-{(1R,2R,3S,4R,5R,6R)-2,3,4,6-tetrakis-benzyloxy-5-[benzyloxy-((R)-2-methoxy-3-octadecyloxy-propoxy)-phosphoryloxy]-cyclohexyl}-methyl)-phosphonic acid dibenzyl ester

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Chemical Property of ((R)-Hydroxy-{(1R,2R,3S,4R,5R,6R)-2,3,4,6-tetrakis-benzyloxy-5-[benzyloxy-((R)-2-methoxy-3-octadecyloxy-propoxy)-phosphoryloxy]-cyclohexyl}-methyl)-phosphonic acid dibenzyl ester

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Technology Process of ((R)-Hydroxy-{(1R,2R,3S,4R,5R,6R)-2,3,4,6-tetrakis-benzyloxy-5-[benzyloxy-((R)-2-methoxy-3-octadecyloxy-propoxy)-phosphoryloxy]-cyclohexyl}-methyl)-phosphonic acid dibenzyl ester

There total 16 articles about ((R)-Hydroxy-{(1R,2R,3S,4R,5R,6R)-2,3,4,6-tetrakis-benzyloxy-5-[benzyloxy-((R)-2-methoxy-3-octadecyloxy-propoxy)-phosphoryloxy]-cyclohexyl}-methyl)-phosphonic acid dibenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: ((R)-Hydroxy-{(1R,2R,3S,4R,5R,6R)-2,3,4,6-tetrakis-benzyloxy-5-[benzyloxy-((R)-2-methoxy-3-octadecyloxy-propoxy)-phosphanyloxy]-cyclohexyl}-methyl)-phosphonic acid dibenzyl ester

: 444902-96-9
((R)-Hydroxy-{(1R,2R,3S,4R,5R,6R)-2,3,4,6-tetrakis-benzyloxy-5-[benzyloxy-((R)-2-methoxy-3-octadecyloxy-propoxy)-phosphoryloxy]-cyclohexyl}-methyl)-phosphonic acid dibenzyl ester

Guidance literature:: With tert.-butylhydroperoxide; In dichloromethane; at 20 ℃;
DOI:10.1016/S0040-4039(02)00354-4

Reference yield:

: 291313-64-9
1D-6-O-benzyl-3-deoxy-6-(hydroxymethyl)-1,2:4,5-di-O-isopropylidene-chiro-inositol

: 444902-96-9
((R)-Hydroxy-{(1R,2R,3S,4R,5R,6R)-2,3,4,6-tetrakis-benzyloxy-5-[benzyloxy-((R)-2-methoxy-3-octadecyloxy-propoxy)-phosphoryloxy]-cyclohexyl}-methyl)-phosphonic acid dibenzyl ester

Guidance literature:: Multi-step reaction with 12 steps

1.1: NaH / dimethylformamide / 0 - 20 °C

2.1: AcCl / CH₂Cl₂; methanol / 20 °C

3.1: NaH / dimethylformamide / 0 - 20 °C

4.1: AcCl / methanol / 20 °C

5.1: Bu₂SnO / toluene / Heating

5.2: CsF / dimethylformamide / 20 °C

6.1: NaH / dimethylformamide / 0 - 20 °C

7.1: DABCO / RhCl(PPh₃)3 / ethanol / Heating

7.2: HCl / acetone / Heating

8.1: Dess-Martin periodinane / CH₂Cl₂

9.1: 42 percent / BuLi / tetrahydrofuran / -78 °C

10.1: 89 percent / CAN / acetonitrile; H₂O / 20 °C

11.1: 1H-tetrazole / CH₂Cl₂ / 20 °C

12.1: t-butyl hydroperoxide / CH₂Cl₂ / 20 °C

With 1,4-diaza-bicyclo[2.2.2]octane; 1H-tetrazole; tert.-butylhydroperoxide; n-butyllithium; ammonium cerium(IV) nitrate; sodium hydride; di(n-butyl)tin oxide; Dess-Martin periodane; acetyl chloride; RhCl(PPh₃)3; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile; 8.1: Dess-Martin oxidation;
DOI:10.1016/S0040-4039(02)00354-4

Reference yield:

: 444902-89-0
(3aR,4R,5R,6S,7R,7aR)-4-Allyloxymethyl-7-benzyloxy-2,2-dimethyl-hexahydro-benzo[1,3]dioxole-5,6-diol

: 444902-96-9
((R)-Hydroxy-{(1R,2R,3S,4R,5R,6R)-2,3,4,6-tetrakis-benzyloxy-5-[benzyloxy-((R)-2-methoxy-3-octadecyloxy-propoxy)-phosphoryloxy]-cyclohexyl}-methyl)-phosphonic acid dibenzyl ester

Guidance literature:: Multi-step reaction with 10 steps

1.1: NaH / dimethylformamide / 0 - 20 °C

2.1: AcCl / methanol / 20 °C

3.1: Bu₂SnO / toluene / Heating

3.2: CsF / dimethylformamide / 20 °C

4.1: NaH / dimethylformamide / 0 - 20 °C

5.1: DABCO / RhCl(PPh₃)3 / ethanol / Heating

5.2: HCl / acetone / Heating

6.1: Dess-Martin periodinane / CH₂Cl₂

7.1: 42 percent / BuLi / tetrahydrofuran / -78 °C

8.1: 89 percent / CAN / acetonitrile; H₂O / 20 °C

9.1: 1H-tetrazole / CH₂Cl₂ / 20 °C

10.1: t-butyl hydroperoxide / CH₂Cl₂ / 20 °C

With 1,4-diaza-bicyclo[2.2.2]octane; 1H-tetrazole; tert.-butylhydroperoxide; n-butyllithium; ammonium cerium(IV) nitrate; sodium hydride; di(n-butyl)tin oxide; Dess-Martin periodane; acetyl chloride; RhCl(PPh₃)3; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile; 6.1: Dess-Martin oxidation;
DOI:10.1016/S0040-4039(02)00354-4