C₂₅H₂₂ClFN₄O₂S

Base Information

• Chemical Name: C₂₅H₂₂ClFN₄O₂S
• CAS No.: 1005459-93-7
• Molecular Formula: C₂₅H₂₂ClFN₄O₂S
• Molecular Weight: 496.993
• Mol file: 1005459-93-7.mol

Synonyms:C₂₅H₂₂ClFN₄O₂S

Chemical Property of C₂₅H₂₂ClFN₄O₂S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of C₂₅H₂₂ClFN₄O₂S

There total 1 articles about C₂₅H₂₂ClFN₄O₂S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

(R,R)-N-(1-phenylethyl)-4-(2-chloro-4-fluorophenyl)-6-methyl-2-(2-thiazolyl)-1,4-dihydropyrimidin-5-carboxamide (1005459-66-4) + acetyl chloride (75-36-5) → C25H22ClFN4O2S (1005459-93-7)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 6h;

Reference yield: 78.0%

C25H22ClFN4O2S (1005459-93-7) → ethyl 4-(R)-(2-chloro-4-fluorophenyl)-2-(thiazol-2-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxylate (247037-81-6)

Guidance literature:

C₂₅H₂₂ClFN₄O₂S; With acetic acid; sodium nitrite; at 0 ℃; for 6h;

With sodium ethanolate; In ethanol; at 0 ℃; for 0.833333h;

With hydrogenchloride; In ethanol; water; pH=7;

Reference yield: 78.0%

C25H22ClFN4O2S (1005459-93-7) + sodium ethanolate (141-52-6) → ethyl (R)-4-(2-chloro-4-fluorophenyl)-6-methyl-2-(2-thiazolyl)-1,4-dihydropyrimidin-5-carboxylate

Guidance literature:

C₂₅H₂₂ClFN₄O₂S; With acetic acid; sodium nitrite; In ethanol; water; ethyl acetate; at 0 ℃; for 6h; Inert atmosphere;

sodium ethanolate; In ethanol; at 0 ℃; for 0.833333h;

upstream raw materials:

(R,R)-N-(1-phenylethyl)-4-(2-chloro-4-fluorophenyl)-6-methyl-2-(2-thiazolyl)-1,4-dihydropyrimidin-5-carboxamide

acetyl chloride

Downstream raw materials:

ethyl 4-(R)-(2-chloro-4-fluorophenyl)-2-(thiazol-2-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxylate

Refernces

• 1、 -. "OPTICAL PURE DIHYDROPYRIMIDINE COMPOUNDS, THEIR USES IN THE MANUFACTURE OF A MEDICAMNENT FOR THE TREATMENT OR THE PREVENTION OF VIROSIS DISEASES". Page/Page column 8; 13. . Retrieved 2009/05/29.