methyl (S)-2-[(N-(o-nitrobenzenesulfonyl)amino)-5-(triisopropylsilyloxy)]pentanoate

Base Information

Chemical Name:methyl (S)-2-[(N-(o-nitrobenzenesulfonyl)amino)-5-(triisopropylsilyloxy)]pentanoate
CAS No.:945493-37-8
Molecular Formula:C₂₁H₃₆N₂O₇SSi
Molecular Weight:488.678
Hs Code.:

Synonyms:methyl (S)-2-[(N-(o-nitrobenzenesulfonyl)amino)-5-(triisopropylsilyloxy)]pentanoate

Suppliers and Price of methyl (S)-2-[(N-(o-nitrobenzenesulfonyl)amino)-5-(triisopropylsilyloxy)]pentanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of methyl (S)-2-[(N-(o-nitrobenzenesulfonyl)amino)-5-(triisopropylsilyloxy)]pentanoate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

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Hazard Codes:

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Technology Process of methyl (S)-2-[(N-(o-nitrobenzenesulfonyl)amino)-5-(triisopropylsilyloxy)]pentanoate

There total 8 articles about methyl (S)-2-[(N-(o-nitrobenzenesulfonyl)amino)-5-(triisopropylsilyloxy)]pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 56-86-0,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6
L-glutamic acid

: 945493-37-8
methyl (S)-2-[(N-(o-nitrobenzenesulfonyl)amino)-5-(triisopropylsilyloxy)]pentanoate

Guidance literature:: Multi-step reaction with 8 steps

1.1: H₂SO₄

1.2: pyridine / ethanol

2.1: triethylamine / dimethylformamide

3.1: potassium carbonate / dimethylformamide

4.1: 42 g / H₂ / Pd/C / ethanol

5.1: triethylamine

6.1: NaBH₄ / methanol; tetrahydrofuran

7.1: triethylamine / dimethylformamide / 5 h / 20 °C

7.2: TFA / CH₂Cl₂ / 1 h / 0 °C

8.1: 4.95 g / triethylamine / CH₂Cl₂

With sodium tetrahydroborate; sulfuric acid; hydrogen; potassium carbonate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/b702649h

Reference yield:

: 59279-58-2
N^α-tert-butyloxycarbonyl-γ-benzyloxycarbonyl-L-glutamic acid methyl ester

: 945493-37-8
methyl (S)-2-[(N-(o-nitrobenzenesulfonyl)amino)-5-(triisopropylsilyloxy)]pentanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 42 g / H₂ / Pd/C / ethanol

2.1: triethylamine

3.1: NaBH₄ / methanol; tetrahydrofuran

4.1: triethylamine / dimethylformamide / 5 h / 20 °C

4.2: TFA / CH₂Cl₂ / 1 h / 0 °C

5.1: 4.95 g / triethylamine / CH₂Cl₂

With sodium tetrahydroborate; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/b702649h

Reference yield:

: 13574-13-5
Boc-Glu(OBzl)-OH

: 945493-37-8
methyl (S)-2-[(N-(o-nitrobenzenesulfonyl)amino)-5-(triisopropylsilyloxy)]pentanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / dimethylformamide

2.1: 42 g / H₂ / Pd/C / ethanol

3.1: triethylamine

4.1: NaBH₄ / methanol; tetrahydrofuran

5.1: triethylamine / dimethylformamide / 5 h / 20 °C

5.2: TFA / CH₂Cl₂ / 1 h / 0 °C

6.1: 4.95 g / triethylamine / CH₂Cl₂

With sodium tetrahydroborate; hydrogen; potassium carbonate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/b702649h