3-O-benzyl-2-O-benzyloxy-N,N-diisopropylaminophosphine-5,6-O-isopropylidene-L-ascorbic acid

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Chemical Name:3-O-benzyl-2-O-benzyloxy-N,N-diisopropylaminophosphine-5,6-O-isopropylidene-L-ascorbic acid
CAS No.:177943-54-3
Molecular Formula:C₂₉H₃₈NO₇P
Molecular Weight:543.597
Hs Code.:

Synonyms:3-O-benzyl-2-O-benzyloxy-N,N-diisopropylaminophosphine-5,6-O-isopropylidene-L-ascorbic acid

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Chemical Property of 3-O-benzyl-2-O-benzyloxy-N,N-diisopropylaminophosphine-5,6-O-isopropylidene-L-ascorbic acid

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Technology Process of 3-O-benzyl-2-O-benzyloxy-N,N-diisopropylaminophosphine-5,6-O-isopropylidene-L-ascorbic acid

There total 3 articles about 3-O-benzyl-2-O-benzyloxy-N,N-diisopropylaminophosphine-5,6-O-isopropylidene-L-ascorbic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 108549-21-9
benzyl-N,N,N',N'-tetraisopropylphosphorodiamidite

: 86404-07-1
O³-benzyl-O⁵,O⁶-(1-methylethylidene)-L-ascorbic acid

: 177943-54-3
3-O-benzyl-2-O-benzyloxy-N,N-diisopropylaminophosphine-5,6-O-isopropylidene-L-ascorbic acid

Guidance literature:: With 1H-tetrazole; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1016/0008-6215(96)00043-2

Reference yield:

: 15042-01-0
5,6-O-isopropylidene-L-ascorbic acid

: 177943-54-3
3-O-benzyl-2-O-benzyloxy-N,N-diisopropylaminophosphine-5,6-O-isopropylidene-L-ascorbic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 47 percent / KHCO₃ / dimethylformamide / 24 h / 20 °C

2: 97 percent / 1H-tetrazole / CH₂Cl₂ / 1 h / 20 °C

With 1H-tetrazole; potassium hydrogencarbonate; In dichloromethane; N,N-dimethyl-formamide; 1: Alkylation / 2: Condensation;
DOI:10.1016/0008-6215(96)00043-2

Reference yield:

: 50-81-7,98966-42-8
ascorbic acid

: 177943-54-3
3-O-benzyl-2-O-benzyloxy-N,N-diisopropylaminophosphine-5,6-O-isopropylidene-L-ascorbic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / AcCl / 4 h / 20 °C

2: 47 percent / KHCO₃ / dimethylformamide / 24 h / 20 °C

3: 97 percent / 1H-tetrazole / CH₂Cl₂ / 1 h / 20 °C

With 1H-tetrazole; potassium hydrogencarbonate; acetyl chloride; In dichloromethane; N,N-dimethyl-formamide; 1: acetonation / 2: Alkylation / 3: Condensation;
DOI:10.1016/0008-6215(96)00043-2