Phosphorous acid benzyl ester (R)-4-benzyloxy-5-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-oxo-2,5-dihydro-furan-3-yl ester (1S,2R,3S,4S,5R,6S)-2,3,4,5,6-pentakis-benzyloxy-cyclohexyl ester

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Chemical Name:Phosphorous acid benzyl ester (R)-4-benzyloxy-5-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-oxo-2,5-dihydro-furan-3-yl ester (1S,2R,3S,4S,5R,6S)-2,3,4,5,6-pentakis-benzyloxy-cyclohexyl ester
CAS No.:177943-53-2
Molecular Formula:C₆₄H₆₅O₁₃P
Molecular Weight:1073.19
Hs Code.:

Phosphorous acid benzyl ester (R)-4-benzyloxy-5-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-oxo-2,5-dihydro-furan-3-yl ester (1S,2R,3S,4S,5R,6S)-2,3,4,5,6-pentakis-benzyloxy-cyclohexyl ester

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Chemical Property of Phosphorous acid benzyl ester (R)-4-benzyloxy-5-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-oxo-2,5-dihydro-furan-3-yl ester (1S,2R,3S,4S,5R,6S)-2,3,4,5,6-pentakis-benzyloxy-cyclohexyl ester

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Technology Process of Phosphorous acid benzyl ester (R)-4-benzyloxy-5-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-oxo-2,5-dihydro-furan-3-yl ester (1S,2R,3S,4S,5R,6S)-2,3,4,5,6-pentakis-benzyloxy-cyclohexyl ester

There total 9 articles about Phosphorous acid benzyl ester (R)-4-benzyloxy-5-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-oxo-2,5-dihydro-furan-3-yl ester (1S,2R,3S,4S,5R,6S)-2,3,4,5,6-pentakis-benzyloxy-cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6195-45-5
meso-1,3,4,5,6-penta-O-benzyl-myo-inositol

: 177943-54-3
3-O-benzyl-2-O-benzyloxy-N,N-diisopropylaminophosphine-5,6-O-isopropylidene-L-ascorbic acid

: 177943-53-2
Phosphorous acid benzyl ester (R)-4-benzyloxy-5-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-oxo-2,5-dihydro-furan-3-yl ester (1S,2R,3S,4S,5R,6S)-2,3,4,5,6-pentakis-benzyloxy-cyclohexyl ester

Guidance literature:: With 1H-tetrazole; In dichloromethane; at 20 ℃; for 96h;
DOI:10.1016/0008-6215(96)00043-2

Reference yield:

: 87-89-8
D-myo-inositol

: 177943-53-2
Phosphorous acid benzyl ester (R)-4-benzyloxy-5-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-oxo-2,5-dihydro-furan-3-yl ester (1S,2R,3S,4S,5R,6S)-2,3,4,5,6-pentakis-benzyloxy-cyclohexyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: p-TsOH / dimethylformamide; toluene / 10 h / 122 - 136 °C

1.2: 98 percent / p-TsOH; EtOH / 48 h / 20 °C

2.1: KOH / 2 h / 115 - 131 °C

3.1: AcOH; water / 4 h / 80 - 105 °C

4.1: 79 percent / NaOH / benzene / 5 h / Heating

5.1: 1H-tetrazole / CH₂Cl₂ / 96 h / 20 °C

With 1H-tetrazole; potassium hydroxide; sodium hydroxide; water; toluene-4-sulfonic acid; acetic acid; In dichloromethane; N,N-dimethyl-formamide; toluene; benzene; 1.1: Condensation / 1.2: alcoholysis / 2.1: Alkylation / 3.1: Hydrolysis / 4.1: Alkylation / 5.1: Condensation;
DOI:10.1016/0008-6215(96)00043-2

Reference yield:

: 6763-47-9,1251832-23-1
rac-1,2-O-cyclohexylidene-myo-inositol

: 177943-53-2
Phosphorous acid benzyl ester (R)-4-benzyloxy-5-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-oxo-2,5-dihydro-furan-3-yl ester (1S,2R,3S,4S,5R,6S)-2,3,4,5,6-pentakis-benzyloxy-cyclohexyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: KOH / 2 h / 115 - 131 °C

2: AcOH; water / 4 h / 80 - 105 °C

3: 79 percent / NaOH / benzene / 5 h / Heating

4: 1H-tetrazole / CH₂Cl₂ / 96 h / 20 °C

With 1H-tetrazole; potassium hydroxide; sodium hydroxide; water; acetic acid; In dichloromethane; benzene; 1: Alkylation / 2: Hydrolysis / 3: Alkylation / 4: Condensation;
DOI:10.1016/0008-6215(96)00043-2